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EGFR-IN-175
Catalog No. T213203 Copy Product Info
🥰Excellent
EGFR-IN-175 is an orally active and selective EGFRL858R/T790M/C797S inhibitor, with an IC50 value of 18.94 nM. It induces apoptosis and causes G1 phase arrest. Additionally, EGFR-IN-175 downregulates the expression of p-EGFR, p-AKT, and p-ERK. It is applicable in cancer research, including studies on lung cancer.
EGFR-IN-175
Copy Product Info🥰Excellent
Catalog No. T213203
EGFR-IN-175 is an orally active and selective EGFRL858R/T790M/C797S inhibitor, with an IC50 value of 18.94 nM. It induces apoptosis and causes G1 phase arrest. Additionally, EGFR-IN-175 downregulates the expression of p-EGFR, p-AKT, and p-ERK. It is applicable in cancer research, including studies on lung cancer.
EGFR-IN-175
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
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| Description | EGFR-IN-175 is an orally active and selective EGFRL858R/T790M/C797S inhibitor, with an IC50 value of 18.94 nM. It induces apoptosis and causes G1 phase arrest. Additionally, EGFR-IN-175 downregulates the expression of p-EGFR, p-AKT, and p-ERK. It is applicable in cancer research, including studies on lung cancer. |
| Targets&IC50 | EGFR WT:125.9 nM |
| In vitro | EGFR-IN-175 (Compound M49) inhibits the proliferation of BaF3-EGFR L858R/T790M/C797S, A431, and H1975 cells with IC50 values of 0.77, 5.11, and 5.94 μM, respectively. In a dose-dependent manner, EGFR-IN-175 (0.1-2.5 μM) reduces the phosphorylation levels of p-EGFR, p-AKT, and p-ERK in BaF3-TM cells. Additionally, EGFR-IN-175 (0.1-2.5 μM, 48 h) induces apoptosis and G1 phase arrest in BaF3-TM cells. |
| In vivo | EGFR-IN-175 (Compound M49) [administered via intraperitoneal injection at 30 mg/kg or orally at 30-60 mg/kg, once daily for 14 days] effectively inhibits tumor growth in BaF3-EGFR L858R/T790M/C797S xenografts in BALB/c nude mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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