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DMHCA

Catalog No. T40898 CAS 79066-03-8

DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in researching cholesterol homeostasis and diabetes.

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DMHCA, CAS 79066-03-8

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2 mg	5 days	$ 59.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in researching cholesterol homeostasis and diabetes.
In vitro	In ex vivo treatment of diabetic CD34+ cells, DMHCA (10 μM; 16-18 hours) effectively restores membrane fluidity to normal, non-diabetic levels and normalizes BM-derived TNF-α and IL-3 levels while significantly reducing CCL-2 production in both BM supernatants and systemic circulation by over 50% compared to control mice[1]. Additionally, DMHCA increases the number of circulating angiogenic cells (CACs) in both BM and peripheral circulation and promotes the release of vascular repair cells into the bloodstream[1]. Through PAGA analysis, it's evident that DMHCA treatment not only boosts the overall production of erythrocyte progenitors but also improves their robustness and flux, resulting in an increased density of erythrocyte progenitors in BM cells. Furthermore, DMHCA expands the proportion of these progenitors and elevates the expression of the hemoglobin beta adult chain (HBB-BT), underscoring its multifaceted role in enhancing erythropoiesis[1].
In vivo	Administered orally for six months at a dosage of 8mg/kg body weight per day in chow, DMHCA effectively restores cholesterol homeostasis in the retina of diabetic subjects. This action is marked by a significant elevation in the concentrations of endogenous LXR ligands, desmosterol, and total oxysterols within the diabetic retina[1].

Molecular Weight	401.635
Formula	C26H43NO2
CAS No.	79066-03-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cristiano P Vieira, et al. Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes. JCI Insight. 2020 Jul 9;5(13):e137230.

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Keywords

DMHCA 79066-03-8 inhibitor inhibit

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