Shopping Cart

Your shopping cart is currently empty

DMHCA

Name: DMHCA
Brand: TargetMol
SKU: T40898
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T40898Cas No. 79066-03-8

DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression.

DMHCA

Copy Product Info

😃Good

Purity: 99.80%

Catalog No. T40898Cas No. 79066-03-8

DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.80%

Appearance:Solid

Color:White to Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description	DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression.
In vitro	Treatment of diabetic CD34+ cells with 10 μM DMHCA restored cell membrane fluidity to non-diabetic baseline levels. DMHCA restored bone marrow-derived TNF-α and IL-3 levels to baseline and significantly reduced CCL-2 production in bone marrow supernatant and systemic circulation. In addition, DMHCA increased the number of circulating vascular progenitor cells (CACs) in the bone marrow and peripheral circulation and facilitated the migration of vascular repair cells into the peripheral circulation. [1]
In vivo	DMHCA was able to restore cholesterol homeostasis in the diabetic retina by oral administration of 8 mg/kg/day for 6 months. In diabetic retina, DMHCA significantly increased the levels of endogenous LXR ligand, norethisterol and total oxidized sterols. [1]

Chemical Properties

Molecular Weight	401.63
Formula	C₂₆H₄₃NO₂
Cas No.	79066-03-8
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(N(C)C)=O)C)[H])[H]
Relative Density.	1.06 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (12.45 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4899 mL	12.4493 mL	24.8985 mL	124.4927 mL
5 mM	0.4980 mL	2.4899 mL	4.9797 mL	24.8985 mL
10 mM	0.2490 mL	1.2449 mL	2.4899 mL	12.4493 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc