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CL075

Name: CL075
Brand: TargetMol
SKU: T27034
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27034Cas No. 256922-53-9

Alias CL-075, 3M002

CL075 (3M002) is a selective TLR8 agonist with immunomodulatory activity, triggering the MyD88-dependent signaling pathway and activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN).

CL075

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Purity: 99.25%

Catalog No. T27034Alias CL-075, 3M002Cas No. 256922-53-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$34	-	In Stock
1 mL x 10 mM (in DMSO)	$85	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.25%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CL075 (3M002) is a selective TLR8 agonist with immunomodulatory activity, triggering the MyD88-dependent signaling pathway and activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN).
In vitro	CL075 (2 μM) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes within 4 hours, stimulates total IgM production and cell proliferation in rabbit splenocytes within 48 hours, and activates rabTLR8 in 293 cells within 7 hours.[1]
In vivo	CL075 (5 μM; s.c.) activates mild antigen-specific antibody responses in rabbits.[1]
Synonyms	CL-075, 3M002

Chemical Properties

Molecular Weight	243.33
Formula	C₁₃H₁₃N₃S
Cas No.	256922-53-9
Smiles	CCCc1nc2c(N)nc3ccccc3c2s1
Relative Density.	1.313 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 19.8 mg/mL (81.37 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1096 mL	20.5482 mL	41.0965 mL	205.4823 mL
5 mM	0.8219 mL	4.1096 mL	8.2193 mL	41.0965 mL
10 mM	0.4110 mL	2.0548 mL	4.1096 mL	20.5482 mL
20 mM	0.2055 mL	1.0274 mL	2.0548 mL	10.2741 mL
50 mM	0.0822 mL	0.4110 mL	0.8219 mL	4.1096 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc