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EMD57439

Name: EMD57439
Brand: TargetMol
SKU: T25373
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25373Cas No. 148714-88-9

Alias EMD-57439, EMD 57439

EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).

EMD57439

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Purity: 99.57%

Catalog No. T25373Alias EMD-57439, EMD 57439Cas No. 148714-88-9

EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$279	In Stock	In Stock
10 mg	$407	In Stock	In Stock
25 mg	$642	In Stock	In Stock
50 mg	$913	In Stock	In Stock
100 mg	$1,250	-	In Stock
200 mg	$1,680	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA HNMR CSFC HPLC ORP

Product Introduction

Bioactivity

Description	EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).
In vitro	EMD 57033 (10 microM) slightly increased the rate of relaxation (rate constant k1 changing from 24.0 +/- 2.9 s-1 in control to 28.1 +/- 3.2 s-1) but had no significant effect on the rate of activation (k1 = 9.6 +/- 0.9 s-1 in control conditions, 9.7 +/- 1.6 s-1 with EMD 57033).[2]
Synonyms	EMD-57439, EMD 57439

Chemical Properties

Molecular Weight	425.5
Formula	C₂₂H₂₃N₃O₄S
Cas No.	148714-88-9
Smiles	O=C(C1=CC(OC)=C(C=C1)OC)N2C3=CC=C(C([C@@H](S4)C)=NNC4=O)C=C3CCC2
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (52.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3502 mL	11.7509 mL	23.5018 mL	117.5088 mL
5 mM	0.4700 mL	2.3502 mL	4.7004 mL	23.5018 mL
10 mM	0.2350 mL	1.1751 mL	2.3502 mL	11.7509 mL
20 mM	0.1175 mL	0.5875 mL	1.1751 mL	5.8754 mL
50 mM	0.0470 mL	0.2350 mL	0.4700 mL	2.3502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc