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GSK1702934A

Name: GSK1702934A
Brand: TargetMol
SKU: T15425
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15425Cas No. 924377-85-5

Alias GSK-1702934A, GSK 1702934A

GSK1702934A, a selective TRPC3 agonist, modulates cardiac contractility and arrhythmogenesis through TRPC3 activation.

GSK1702934A

🥰Excellent

Purity: 98.15%

Catalog No. T15425Alias GSK-1702934A, GSK 1702934ACas No. 924377-85-5

GSK1702934A, a selective TRPC3 agonist, modulates cardiac contractility and arrhythmogenesis through TRPC3 activation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.15%

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COA LCMS

Product Introduction

Bioactivity

Description	GSK1702934A, a selective TRPC3 agonist, modulates cardiac contractility and arrhythmogenesis through TRPC3 activation.
In vitro	GSK1702934A is capable of inducing TRPC3/6 currents in HEK293 cells transfected with recombinant human TRPC3/6 at EC50 values of 0.08 mM and 0.44 mM respectively, triggering transient, non-selective conductance and prolongation of action potentials in myocytes overexpressing TRPC3, and markedly enhancing NCX currents; however, these effects are not observed in wild-type myocytes[2].
Synonyms	GSK-1702934A, GSK 1702934A

Chemical Properties

Molecular Weight	395.52
Formula	C₂₂H₂₅N₃O₂S
Cas No.	924377-85-5
Smiles	O=C(N1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cc2CCCCCc2s1
Relative Density.	1.299 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (202.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5283 mL	12.6416 mL	25.2832 mL	126.4159 mL
5 mM	0.5057 mL	2.5283 mL	5.0566 mL	25.2832 mL
10 mM	0.2528 mL	1.2642 mL	2.5283 mL	12.6416 mL
20 mM	0.1264 mL	0.6321 mL	1.2642 mL	6.3208 mL
50 mM	0.0506 mL	0.2528 mL	0.5057 mL	2.5283 mL
100 mM	0.0253 mL	0.1264 mL	0.2528 mL	1.2642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc