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RY796

Name: RY796
Brand: TargetMol
SKU: T16815
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16815Cas No. 1393441-53-6

Alias RY 796

RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.

RY796

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Purity: 98.59%

Catalog No. T16815Alias RY 796Cas No. 1393441-53-6

RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.59%

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Product Introduction

Bioactivity

Description	RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.
Targets&IC50	Kv2.2 channel:0.09 μM, Kv2.1 channel:0.25 μM
In vitro	RY796 is a potent selective voltage-gated potassium (KV2) channel inhibitor with IC50 values of 0.25 μM and 0.09 μM for KV2.1 and KV2.2, respectively. [1]
In vivo	Inhibition of Kv2.x channel by RY796 enhanced GSIS in isolated wild-type (WT) mice and human islets. [2]
Synonyms	RY 796

Chemical Properties

Molecular Weight	353.46
Formula	C₂₁H₂₇N₃O₂
Cas No.	1393441-53-6
Smiles	C(N[C@H](C)C1=CC=CC=C1)(=O)C2=C(N(C)C)C=CC(NC(C(C)C)=O)=C2
Relative Density.	1.132 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (226.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8292 mL	14.1459 mL	28.2917 mL	141.4587 mL
5 mM	0.5658 mL	2.8292 mL	5.6583 mL	28.2917 mL
10 mM	0.2829 mL	1.4146 mL	2.8292 mL	14.1459 mL
20 mM	0.1415 mL	0.7073 mL	1.4146 mL	7.0729 mL
50 mM	0.0566 mL	0.2829 mL	0.5658 mL	2.8292 mL
100 mM	0.0283 mL	0.1415 mL	0.2829 mL	1.4146 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc