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NG-Nitroarginine methyl ester

Name: NG-Nitroarginine methyl ester
Brand: TargetMol
SKU: T25865
Rating: 4.5 (1 reviews)

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Catalog No. T25865Cas No. 50903-99-6

Alias ω-Nitroarginine methyl, L-NAME

NG-Nitroarginine methyl ester (ω-Nitroarginine methyl) is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.

NG-Nitroarginine methyl ester

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Catalog No. T25865Alias ω-Nitroarginine methyl, L-NAMECas No. 50903-99-6

NG-Nitroarginine methyl ester (ω-Nitroarginine methyl) is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	Inquiry	Inquiry
2 mg	$126	Inquiry	Inquiry
5 mg	$197	Inquiry	Inquiry
10 mg	$298	Inquiry	Inquiry
25 mg	$476	Inquiry	Inquiry
50 mg	$678	Inquiry	Inquiry
100 mg	$912	Inquiry	Inquiry
200 mg	$1,190	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$179	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

NG-Nitroarginine methyl ester AI Summary

NG-Nitroarginine methyl ester is a potent inhibitor of nitric oxide synthase (NOS) enzymes, demonstrating activity across various cell types and conditions. It inhibits endothelial nitric oxide synthesis with an IC50 of 1500.0 nM, neuronal nitric oxide synthesis with an IC50 of 1600.0 nM, and inducible nitric oxide synthesis with an IC50 of 8000.0 nM in human recombinant assays. In intact cell studies, it inhibits nitric oxide production in DLD-1 cells and macrophages (e.g., J774A1 and RAW264.7) with IC50 values varying from 2600.0 nM to over 300000.0 nM. Additionally, it shows significant anti-inflammatory activity by reducing LPS and IFN-gamma-induced nitric oxide production in mouse microglial BV2 cells and RAW264.7 cells with IC50 values ranging from 13350.0 nM to 57000.0 nM. NG-Nitroarginine methyl ester also exhibits selectivity towards distinct NOS isoforms and shows promising anti-inflammatory and gastroprotective effects in animal models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NG-Nitroarginine methyl ester (ω-Nitroarginine methyl) is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.
Synonyms	ω-Nitroarginine methyl, L-NAME

Chemical Properties

Molecular Weight	233.23
Formula	C₇H₁₅N₅O₄
Cas No.	50903-99-6
Smiles	[C@H](CCCNC(NN(=O)=O)=N)(C(OC)=O)N
Relative Density.	1.48g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.34 mg/mL (10.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2876 mL	21.4381 mL	42.8761 mL	214.3807 mL
5 mM	0.8575 mL	4.2876 mL	8.5752 mL	42.8761 mL
10 mM	0.4288 mL	2.1438 mL	4.2876 mL	21.4381 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc