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RF9 acetate

Name: RF9 acetate
Brand: TargetMol
SKU: T16738L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16738L

RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

RF9 acetate

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Purity: 99.77%

Catalog No. T16738L

RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$76	-	In Stock
10 mg	$115	-	In Stock
25 mg	$206	-	In Stock
50 mg	$295	-	In Stock
100 mg	$407	-	In Stock
1 mL x 10 mM (in DMSO)	$102	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.77%

Appearance:Solid

Color:White

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COA LCMS MS

Product Introduction

Bioactivity

Description	RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
Targets&IC50	NPFF2 (human):75 nM (Ki), NPFF1 (human):58 nM (Ki)
In vitro	In Neuro 2A cells, Pretrement of RF9 acetate (10 μM) completely blocks NPFF induced neurite outgrowth[2].
In vivo	RF9 acetate (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked When RF9 acetate is applied in conjunction with NPFF. RF9 acetate (0.1 mg/kg, s.c. min before 0.3 mg/kg heroin or saline on basal nociceptive threshold) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance[2].

Chemical Properties

Molecular Weight	542.67
Formula	C₂₈H₄₂N₆O₅
Smiles	O=C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)CCC/N=C(N)\N)C(C2)(C3)CC4CC3CC2C4.CC(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (101.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8427 mL	9.2137 mL	18.4274 mL	92.1370 mL
5 mM	0.3685 mL	1.8427 mL	3.6855 mL	18.4274 mL
10 mM	0.1843 mL	0.9214 mL	1.8427 mL	9.2137 mL
20 mM	0.0921 mL	0.4607 mL	0.9214 mL	4.6069 mL
50 mM	0.0369 mL	0.1843 mL	0.3685 mL	1.8427 mL
100 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.9214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc