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IDD388
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Catalog No. T27583Cas No. 314297-26-2
Alias IDD-388, IDD 388
IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.
IDD388
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Purity: 99.81%
Catalog No. T27583Alias IDD-388, IDD 388Cas No. 314297-26-2
IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $56 | - | In Stock | |
| 5 mg | $137 | - | In Stock | |
| 10 mg | $227 | - | In Stock | |
| 25 mg | $392 | - | In Stock | |
| 50 mg | $530 | - | In Stock | |
| 100 mg | $732 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
Appearance:Solid
Color:White
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Product Introduction
IDD388 AI Summary
IDD388 is reported to exhibit bioactivity as an inhibitor of human Aldose Reductase 2 (ALR2). It has been shown to effectively inhibit this enzyme with IC50 values of 30.0 nM and 400.0 nM in different assay setups. The latter involved using D,L-glyceraldehyde as a substrate, preincubated for 5 minutes in the presence of NADPH, followed by substrate addition and measurement after 3 minutes using a UV-visible spectrophotometric assay. This data indicates its potency in inhibiting ALR2 at relatively low concentrations..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor. |
| Targets&IC50 | ALR2:30 nM |
| Synonyms | IDD-388, IDD 388 |
| Molecular Weight | 416.63 |
| Formula | C16H12BrClFNO4 |
| Cas No. | 314297-26-2 |
| Smiles | C(NCC1=C(F)C=C(Br)C=C1)(=O)C2=C(OCC(O)=O)C=C(Cl)C=C2 |
| Relative Density. | 1.615 g/cm3 (Predicted) |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (96.01 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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