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V-11-0711 hydrochloride
Catalog No. T214387 Copy Product Info
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V-11-0711 (hydrochloride) is a potent and selective Chk-α inhibitor with an IC50 of 20 nM. This compound significantly reduces PCho levels and can cause reversible growth arrest. At high concentrations, V-11-0711 (hydrochloride) induces apoptosis. It is applicable in research on cervical cancer and triple-negative breast cancer.
V-11-0711 hydrochloride
Copy Product Info🥰Excellent
Catalog No. T214387
V-11-0711 (hydrochloride) is a potent and selective Chk-α inhibitor with an IC50 of 20 nM. This compound significantly reduces PCho levels and can cause reversible growth arrest. At high concentrations, V-11-0711 (hydrochloride) induces apoptosis. It is applicable in research on cervical cancer and triple-negative breast cancer.
V-11-0711 hydrochloride
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | V-11-0711 (hydrochloride) is a potent and selective Chk-α inhibitor with an IC50 of 20 nM. This compound significantly reduces PCho levels and can cause reversible growth arrest. At high concentrations, V-11-0711 (hydrochloride) induces apoptosis. It is applicable in research on cervical cancer and triple-negative breast cancer. |
| Targets&IC50 | Chkα:20 nM nM |
| In vitro | V-11-0711 (hydrochloride), at concentrations of 0.1-10 μM over 48 hours, reduces the levels of PC and GPC in MDA-MB-231 and SUM149 cells. It does not decrease Chk-α protein levels in SUM149 cells at low doses, but it reduces them by approximately 50% at higher doses. At a 10 μM concentration, it significantly lowers PtdCho levels and raises fatty acid levels in SUM149 cells. Additionally, V-11-0711 increases the number of lipid droplets in these cells by about 1.8 times at 10 μM. At this concentration, it also induces apoptosis in SUM149 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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