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BIM-23190 aceate

Catalog No. T39262L

BIM-23190 aceate, a somatostatin analog, a selective agonist of SSTR2 and SSTR5. BIM-23190 can be used in cancer and acromegaly studies.

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BIM-23190 aceate, CAS N/A

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BIM-23190 aceate, a somatostatin analog, a selective agonist of SSTR2 and SSTR5. BIM-23190 can be used in cancer and acromegaly studies.
Targets&IC50	SST5:11.1 nM(Kd), SST2:0.34 nM(Kd)
In vitro	BIM-23190 tends to mildly stimulate PRL secretion. The Ki values are 0.34 nM and 11.1 nM for SSTR2 and SSTR5, respectively[3].
In vivo	In male athymic nude (nu/nu) mice, BIM-23190 (50 μg/mouse, twice a day) significantly reduced the tumor growth rate and exhibited significant anti-tumor (C6 glioma) activity[1].

Molecular Weight	1262.5
Formula	C59H83N13O14S2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Federica Barbieri, et al. Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1078-88. 2. T J Gillespie, et al. Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J Pharmacol Exp Ther. 1998 Apr;285(1):95-104. 3. I Shimon, et al. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997 Nov 1;100(9):2386-92.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BIM-23190 aceate BIM23190 aceate BIM 23190 aceate Inhibitor inhibitor inhibit

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