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L-365260

Name: L-365260
Brand: TargetMol
SKU: T22895
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22895Cas No. 118101-09-0

Alias L365260, L-365,260, L 365260

L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases.

L-365260

🥰Excellent

Purity: 99.75%

Catalog No. T22895Alias L365260, L-365,260, L 365260Cas No. 118101-09-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases.
Targets&IC50	Gastrin:1.9 nM (Ki), Gastrin/CCK-B:2.0 nM (Ki)
In vitro	L-365260 is a compound with high affinity for CCK-B receptors in the brains of various species, which significantly attenuates CCK8S- and CCK4-mediated neuronal depolarization, and has lower affinity for CCK-B and gastrin receptors in dog tissues[1].
In vivo	In male Sprague-Dawley rats (300-350 g), L-365260 (0.01, 0.05, 0.1, 0.2, 0.75, 1.0, 10.0 mg/kg; subcutaneous injection) enhances the analgesic effects[3].
Synonyms	L365260, L-365,260, L 365260

Chemical Properties

Molecular Weight	398.46
Formula	C₂₄H₂₂N₄O₂
Cas No.	118101-09-0
Smiles	CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: <39.85 mg/mL, Sonication is recommended.

DMSO: 80 mg/mL (200.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5097 mL	12.5483 mL	25.0966 mL	125.4831 mL
5 mM	0.5019 mL	2.5097 mL	5.0193 mL	25.0966 mL
10 mM	0.2510 mL	1.2548 mL	2.5097 mL	12.5483 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2742 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5097 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc