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PROTAC HDAC6 degrader 5
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Catalog No. T210684
PROTACHDAC6 degrader 5 (Compound 5a) is a highly selective PROTAC that targets HDAC6. It effectively degrades HDAC6 in cells with an IC50 of 43 nM. This compound reduces HDAC6 levels through a proteasome-dependent mechanism that relies on CRBN.
PROTAC HDAC6 degrader 5
PROTAC HDAC6 degrader 5
😃Good
Catalog No. T210684
PROTACHDAC6 degrader 5 (Compound 5a) is a highly selective PROTAC that targets HDAC6. It effectively degrades HDAC6 in cells with an IC50 of 43 nM. This compound reduces HDAC6 levels through a proteasome-dependent mechanism that relies on CRBN.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTACHDAC6 degrader 5 (Compound 5a) is a highly selective PROTAC that targets HDAC6. It effectively degrades HDAC6 in cells with an IC50 of 43 nM. This compound reduces HDAC6 levels through a proteasome-dependent mechanism that relies on CRBN. |
| Targets&IC50 | HDAC1 (human):162 nM |
| In vitro | PROTAC HDAC6 degrader 5 (Compound 5a) at 1 μM for 48 hours disrupts α-SMA fiber structures induced by TGF-β1 in IMR-90 cells, reversing myofibroblast differentiation. At concentrations of 1 μM and 10 μM over 3-48 hours, it significantly reduces HDAC6 protein levels in IMR-90 cells. At 0.1 μM and 1 μM for 24 hours, it effectively degrades HDAC6 and restores α-tubulin acetylation in a concentration-dependent manner. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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