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UVI 3003

Name: UVI 3003
Brand: TargetMol
SKU: T17209
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17209Cas No. 847239-17-2

UVI 3003 is a highly selective antagonist of the retinoid X receptor, inhibiting Xenopus and human RXRα in Cos7 cells with IC50 values of 0.22 μM and 0.24 μM, respectively.

UVI 3003

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Purity: 99.82%

Catalog No. T17209Cas No. 847239-17-2

UVI 3003 is a highly selective antagonist of the retinoid X receptor, inhibiting Xenopus and human RXRα in Cos7 cells with IC50 values of 0.22 μM and 0.24 μM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$255	In Stock	In Stock
50 mg	$428	In Stock	In Stock
100 mg	$639	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	UVI 3003 is a highly selective antagonist of the retinoid X receptor, inhibiting Xenopus and human RXRα in Cos7 cells with IC50 values of 0.22 μM and 0.24 μM, respectively.
Targets&IC50	RXRα:0.24 μM(Human RXRα, in Cos7 cells), RXRα:0.22 μM(Xenopus RXRα, in Cos7 cells)
In vitro	UVI3003 fully activates xPPARγ (EC50: 12.6 μM) and is almost completely inactive on hPPARγ and mPPARγ. UVI 3003 causes a 65.4% difference in EECD34 cell fusion and desmin expression. UVI 3003 (10 μM) does not change the proliferation rate of extraocular muscles (EOM)-derived or LEG-derived EECD34 cells [1][2].

Chemical Properties

Molecular Weight	436.58
Formula	C₂₈H₃₆O₄
Cas No.	847239-17-2
Smiles	CCCCCOc1cc2c(cc1-c1cc(\C=C\C(O)=O)ccc1O)C(C)(C)CCC2(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (229.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2905 mL	11.4527 mL	22.9053 mL	114.5265 mL
5 mM	0.4581 mL	2.2905 mL	4.5811 mL	22.9053 mL
10 mM	0.2291 mL	1.1453 mL	2.2905 mL	11.4527 mL
20 mM	0.1145 mL	0.5726 mL	1.1453 mL	5.7263 mL
50 mM	0.0458 mL	0.2291 mL	0.4581 mL	2.2905 mL
100 mM	0.0229 mL	0.1145 mL	0.2291 mL	1.1453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc