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MAGL-IN-13
🥰Excellent
Catalog No. T209176
MAGL-IN-13 (compound(3R,4S)-5v) is a selective, irreversible MAGL inhibitor with IC50 values of 0.026 nM for mMAGL, 0.021 nM for hMAGL, and 0.24 nM for rMAGL. Additionally, MAGL-IN-13 is capable of crossing the blood-brain barrier.
MAGL-IN-13
MAGL-IN-13
🥰Excellent
Catalog No. T209176
MAGL-IN-13 (compound(3R,4S)-5v) is a selective, irreversible MAGL inhibitor with IC50 values of 0.026 nM for mMAGL, 0.021 nM for hMAGL, and 0.24 nM for rMAGL. Additionally, MAGL-IN-13 is capable of crossing the blood-brain barrier.
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Product Introduction
Bioactivity
Chemical Properties
| Description | MAGL-IN-13 (compound(3R,4S)-5v) is a selective, irreversible MAGL inhibitor with IC50 values of 0.026 nM for mMAGL, 0.021 nM for hMAGL, and 0.24 nM for rMAGL. Additionally, MAGL-IN-13 is capable of crossing the blood-brain barrier. |
| In vitro | MAGL-IN-13, when pre-incubated at 37℃ for 10 minutes, inhibits mMAGL, hMAGL, and rMAGL with IC50 values of 0.026, 0.021, and 0.24 nM, respectively. It irreversibly inhibits MAGL activity. MAGL-IN-13, at 0.1 and 1 μM, exhibits selectivity for MAGL. In NIH3T3 mouse fibroblasts, it shows low cytotoxicity with a cell viability IC50 of 0.47 μM. At a concentration of 10 μM, it can inhibit Ca2+ channels in rats. |
| In vivo | Administered intraperitoneally at a dose of 5 mg/kg, MAGL-IN-13 effectively suppresses brain MAGL activity in a dose-dependent manner. Animal Model: Adult male mice with MAGL inhibition. |
| Formula | C28H24FN5O4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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