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DDC-01-163
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Catalog No. T203074Cas No. 2140806-84-2
DDC-01-163 is a selective PROTAC degrader targeting EGFR mutants, with an IC50 of 45 nM.
DDC-01-163
😃Good
Catalog No. T203074Cas No. 2140806-84-2
DDC-01-163 is a selective PROTAC degrader targeting EGFR mutants, with an IC50 of 45 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | DDC-01-163 is a selective PROTAC degrader targeting EGFR mutants, with an IC50 of 45 nM. |
| In vitro | DDC-01-163 (0-10 μM) inhibits the proliferation of L858R/T790M EGFR mutant Ba/F3 cells in a concentration-dependent manner, without affecting wild-type EGFR-Ba/F3 cells. In L858R/T790M cells, DDC-01-163 shows IC 50 /EC 50 values for EGFR of 96 nM. |
| Molecular Weight | 942.05 |
| Formula | C49H51N9O9S |
| Cas No. | 2140806-84-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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