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E6AP-mimicking peptide
🥰Excellent
Catalog No. TP3594
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible, and potent peptide-based covalent inhibitor of the HPV16 E6 oncoprotein, utilizing a cysteine-reactive acrylamide warhead to target 16E6. The E6AP-mimicking peptide has an inhibition constant (Ki) of 17 nM and targets all residues emerging in the E6 binding pocket to disrupt the 16E6 and E6AP binding interface. It selectively binds and cross-links MBP-16E6 in PBS or protein mixtures.
E6AP-mimicking peptide
E6AP-mimicking peptide
🥰Excellent
Catalog No. TP3594
E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible, and potent peptide-based covalent inhibitor of the HPV16 E6 oncoprotein, utilizing a cysteine-reactive acrylamide warhead to target 16E6. The E6AP-mimicking peptide has an inhibition constant (Ki) of 17 nM and targets all residues emerging in the E6 binding pocket to disrupt the 16E6 and E6AP binding interface. It selectively binds and cross-links MBP-16E6 in PBS or protein mixtures.
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Product Introduction
Bioactivity
Chemical Properties
| Description | E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible, and potent peptide-based covalent inhibitor of the HPV16 E6 oncoprotein, utilizing a cysteine-reactive acrylamide warhead to target 16E6. The E6AP-mimicking peptide has an inhibition constant (Ki) of 17 nM and targets all residues emerging in the E6 binding pocket to disrupt the 16E6 and E6AP binding interface. It selectively binds and cross-links MBP-16E6 in PBS or protein mixtures. |
| Formula | C128H193N31O29 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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