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Search Result

Search Results for " 3clpro "

Targets

Antiviral SARS-CoV

65

Compounds

3

Natural Products

24

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T77652 SARS-CoV-2 3CLpro-IN-20 Antiviral , SARS-CoV
SARS-CoV-2 3CLpro-IN-20 is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM,).SARS-CoV-2 3CLpro-IN-20 has potential antiviral activity.
T79659 SARS-CoV-2 3CLpro-IN-16 SARS-CoV
SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.
T61774 SARS 3CLpro-IN-1
SARS 3CLpro-IN-1 (Compound 3b) is a stereo-specific SARS 3CL protease inhibitor that belongs to the octahydroisochromene scaffold. It demonstrates inhibition against the P1 site imidazole, with an IC50 value of 95 μM [1]...
T9351 Nirmatrelvir SARS-CoV
PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
T79660 SARS-CoV-2 3CLpro-IN-17 SARS-CoV
Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].
T63385 SARS-CoV-2 3CLpro-IN-2
SARS-CoV-2 3CLpro-IN-2 is a potent inhibitor of the 3CL protease pair and has shown research potential for SARS-CoV-2 disease.
T79376 SARS-CoV-2 3CLpro-IN-19 SARS-CoV
SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of 0.7 μM. It demonstrates broad-spectrum efficacy against inf...
T72370 SARS-CoV-2 3CLpro-IN-6
SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor targeting the SARS-CoV-2 3CL protease, demonstrating potent inhibitory activity with an IC50 of 4.9 μM. It is utilized in the research of coronavirus disease 2019...
T79661 SARS-CoV-2 3CLpro-IN-18 SARS-CoV
SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent inhibitor of SARS-CoV-2 3CLpro with an IC50 of 0.478 μM. It demonstrates inhibition of SARS-CoV-2 in Vero E6 cells, with an EC50 of 2.499 μM, and exhibits low cytotoxic...
T79676 SARS-CoV-2 3CLpro-IN-21 Virus Protease
SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 μM. Additionally, it exhibits inhibitory activity against SARS-CoV-...
T72313 SARS-CoV-2 3CLpro-IN-11
SARS-CoV-2 3CLpro-IN-11(11d) is a broad-spectrum antiviral compound that effectively inhibits the SARS-CoV-2 3CL protease, achieving an IC50 of 140 nM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 and...
T62734 SARS-CoV-2 3CLpro-IN-4
SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a multifunctional inhibitor of SARS CoV-2 3CLpro, exhibiting antiviral, antibacterial, and antifungal activities.
T63679 SARS-CoV-2 3CLpro-IN-3
SARS-CoV-2 3CLpro-IN-3 is a SARS CoV-2 3CLpro inhibitor that exhibits antiviral, antibacterial, and antifungal effects.
T72364 SARS-CoV-2 3CLpro-IN-5 SARS-CoV
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), exhibiting potent inhibitory activity with an IC50 of 3.8 nM and demonstrating 9.0% oral bioavailability (BA). It is utilized in the...
T79462 SARS-CoV-2 3CLpro-IN-14 SARS-CoV
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μM and exhibits minimal cytotoxicity, having a CC50 greater ...
T80657 SARS-CoV-2 3CLpro-IN-15 Virus Protease
SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral replication and transcription. It is instrumental in the id...
T72371 SARS-CoV-2 3CLpro-IN-7
SARS-CoV-2 3CLpro-IN-7 is a reversible covalent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an inhibitory concentration (IC50) value of 1.4 µM.
T63537 SARS-CoV-2 3CLpro-IN-1
SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This partic...
T74807 SARS-CoV-2 3CLpro-IN-13
SARS-CoV-2 3CLpro-IN-13 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating significant anti-coronavirus activity with an IC50 value of 21 nM [1].
T72312 SARS-CoV-2 3CLpro-IN-10
SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 190 nM, and demonstrates varied efficiency against other coronaviruses with IC50 values of 790 nM for SARS-CoV...
T9458 PF-00835231 SARS-CoV
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen i...
T5188 GC376 sodium SARS-CoV
GC376 is an inhibitor of 3C-like proteases (3CLpro) with IC50 values range from 0.49~4.35 μM.
T8371 ML188 Virus Protease , SARS-CoV
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
T9672 GRL-0496 SARS-CoV
GRL-0496 is a potent inhibitor with an enzyme inhibitory activity against SARS-CoV 3CLpro with an IC50 of 30 nM and antiviral potency with an EC50 value of 6.9 μM.
T4578 Tipranavir PNU-140690 SARS-CoV , HIV Protease
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple...
T6388 Amprenavir 141W94,Prozei,KVX-478,VX-478 SARS-CoV , HIV Protease
Amprenavir (KVX-478) is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
T4474 Asunaprevir BMS-650032 HCV Protease , SARS-CoV
Asunaprevir (BMS-650032) is an effective hepatitis C virus (HCV) NS3 protease inhibitor.
T60095 CCF0058981 SARS-CoV
CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-...
T4686 Simeprevir TMC435,TMC-435350,Olysio HCV Protease , SARS-CoV
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.
T5126 Glecaprevir ABT-493 HCV Protease , SARS-CoV
Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).
T6190 Telaprevir VX-950,LY-570310,Incivek,MP-424 HCV Protease , SARS-CoV
Telaprevir (Incivek) (VX-950) is an effective inhibitor of HCV NS3-4A serine protease (IC50: 0.35 μM).
T7903 Saquinavir Ro 31-8959 SARS-CoV , HIV Protease
Saquinavir (Ro 31-8959) is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.
T0100L Atazanavir Zrivada,Reyataz,Latazanavir,BMS-232632 P450 , SARS-CoV , HIV Protease , P-gp
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
T5863 Indinavir sulfate L735524 sulfate,MK-639 sulfate SARS-CoV , HIV Protease
Indinavir sulfate (L735524 sulfate) is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
T22394 Paritaprevir ABT450,ABT-450,Veruprevir HCV Protease
Paritaprevir (ABT450) is an inhibitor of non-structural protein 3/4A protease with EC50 values of 1 and 0.21 nM for HCV 1a and HCV 1b, respectively.
T6025 Danoprevir R7227,ITMN-191,RG7227,RO5190591 HCV Protease , SARS-CoV
Danoprevir (RG7227) is a peptidomimetic inhibitor of the NS3/4A protease(IC50=0.2-3.5 nM) of hepatitis C virus (HCV).
T1525 Ritonavir RTV,Abbott 84538,A 84538,ABT 538 Apoptosis , SARS-CoV , HIV Protease
Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cy...
T0100 Atazanavir sulfate BMS-232632,BMS-232632 sulfate P450 , SARS-CoV , HIV Protease , P-gp
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
T4988 Boceprevir SCH 503034,EBP 520 HCV Protease , SARS-CoV
Boceprevir (SCH 503034) is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-based replicon assay.
T1623 Lopinavir ABT-378 SARS-CoV , HIV Protease
Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related dr...
T4547 Grazoprevir MK-5172 HCV Protease , SARS-CoV
Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1a), 0.08 nM (gt2a), 0.90 nM (gt3a), 0.01 nM (gt1b), ...
T14968 Cinanserin hydrochloride SQ 10643 Influenza Virus , 5-HT Receptor
Cinanserin hydrochloride (SQ 10643) is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.
T3334 Velpatasvir GS-5816 HCV Protease , SARS-CoV
Velpatasvir (GS-5816), also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrier to resistance in HCV replicon assays. GS-5816 d...
T6738 Z-FA-FMK SARS-CoV , Cysteine Protease
Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T9716 Ensitrelvir S-217622 SARS-CoV
Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM.
T68674 Vincapusine
Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.
T9686 YH-53
YH-53 is a potent 3CLpro inhibitor, exhibiting K i values of 6.3 nM and 34.7 nM against SARS-CoV-1 3CLpro and SARS-CoV-2 3CLpro, respectively. This peptidomimetic compound, characterized by its unique benzothiazolyl keto...
T63461 INSCoV-600K(1)
INSCoV-600K(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600K(1) has shown research potential against SARS-CoV-2 infection.
T63483 INSCoV-614(1B)
INSCoV-614(1B) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-614(1B) has shown research potential for SARS-CoV-2 infection.
T63462 INSCoV-601I(1)
INSCoV-601I(1) is a potent Mpro(3CLpro) inhibitor. Proteases (PLpro and 3CLpro) are associated with viral transcription and replication. INSCoV-600I(1) has shown research potential against SARS-CoV-2 infection.

Compounds

SARS-CoV-2 3CLpro-IN-20
T77652
Synonym:
Target: Antiviral, SARS-CoV
SARS-CoV-2 3CLpro-IN-16
T79659
Synonym:
Target: SARS-CoV
SARS 3CLpro-IN-1
T61774
Synonym:
Target:
Nirmatrelvir
T9351
Synonym:
Target: SARS-CoV
SARS-CoV-2 3CLpro-IN-17
T79660
Synonym:
Target: SARS-CoV
SARS-CoV-2 3CLpro-IN-2
T63385
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-19
T79376
Synonym:
Target: SARS-CoV
SARS-CoV-2 3CLpro-IN-6
T72370
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-18
T79661
Synonym:
Target: SARS-CoV
SARS-CoV-2 3CLpro-IN-21
T79676
Synonym:
Target: Virus Protease
SARS-CoV-2 3CLpro-IN-11
T72313
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-4
T62734
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-3
T63679
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-5
T72364
Synonym:
Target: SARS-CoV
SARS-CoV-2 3CLpro-IN-14
T79462
Synonym:
Target: SARS-CoV
SARS-CoV-2 3CLpro-IN-15
T80657
Synonym:
Target: Virus Protease
SARS-CoV-2 3CLpro-IN-7
T72371
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-1
T63537
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-13
T74807
Synonym:
Target:
SARS-CoV-2 3CLpro-IN-10
T72312
Synonym:
Target:
PF-00835231
T9458
Synonym:
Target: SARS-CoV
GC376 sodium
T5188
Synonym:
Target: SARS-CoV
ML188
T8371
Synonym:
Target: Virus Protease, SARS-CoV
GRL-0496
T9672
Synonym:
Target: SARS-CoV
Tipranavir
T4578
Synonym: PNU-140690
Target: SARS-CoV, HIV Protease
Amprenavir
T6388
Synonym: 141W94,Prozei,KVX-478,VX-478
Target: SARS-CoV, HIV Protease
Asunaprevir
T4474
Synonym: BMS-650032
Target: HCV Protease, SARS-CoV
CCF0058981
T60095
Synonym:
Target: SARS-CoV
Simeprevir
T4686
Synonym: TMC435,TMC-435350,Olysio
Target: HCV Protease, SARS-CoV
Glecaprevir
T5126
Synonym: ABT-493
Target: HCV Protease, SARS-CoV
Telaprevir
T6190
Synonym: VX-950,LY-570310,Incivek,MP-424
Target: HCV Protease, SARS-CoV
Saquinavir
T7903
Synonym: Ro 31-8959
Target: SARS-CoV, HIV Protease
Atazanavir
T0100L
Synonym: Zrivada,Reyataz,Latazanavir,BMS-232632
Target: P450, SARS-CoV, HIV Protease, P-gp
Indinavir sulfate
T5863
Synonym: L735524 sulfate,MK-639 sulfate
Target: SARS-CoV, HIV Protease
Paritaprevir
T22394
Synonym: ABT450,ABT-450,Veruprevir
Target: HCV Protease
Danoprevir
T6025
Synonym: R7227,ITMN-191,RG7227,RO5190591
Target: HCV Protease, SARS-CoV
Ritonavir
T1525
Synonym: RTV,Abbott 84538,A 84538,ABT 538
Target: Apoptosis, SARS-CoV, HIV Protease
Atazanavir sulfate
T0100
Synonym: BMS-232632,BMS-232632 sulfate
Target: P450, SARS-CoV, HIV Protease, P-gp
Boceprevir
T4988
Synonym: SCH 503034,EBP 520
Target: HCV Protease, SARS-CoV
Lopinavir
T1623
Synonym: ABT-378
Target: SARS-CoV, HIV Protease
Grazoprevir
T4547
Synonym: MK-5172
Target: HCV Protease, SARS-CoV
Cinanserin hydrochloride
T14968
Synonym: SQ 10643
Target: Influenza Virus, 5-HT Receptor
Velpatasvir
T3334
Synonym: GS-5816
Target: HCV Protease, SARS-CoV
Z-FA-FMK
T6738
Synonym:
Target: SARS-CoV, Cysteine Protease
Ensitrelvir
T9716
Synonym: S-217622
Target: SARS-CoV
Vincapusine
T68674
Synonym:
Target:
YH-53
T9686
Synonym:
Target:
INSCoV-600K(1)
T63461
Synonym:
Target:
INSCoV-614(1B)
T63483
Synonym:
Target:
INSCoV-601I(1)
T63462
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T3921 Punicalagin SARS-CoV , HBV
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumula...
TN2302 Viscidulin III Ganhuangenin Glucosidase
Viscidulin III (Ganhuangenin) is present in Scutellaria baicalensis and acts as an α-glucosidase inhibitor.
T80010 (25S)-Antcin B SARS-CoV
Antcin-B exhibits a high-affinity inhibition of 3CLPro, which is potentially significant in SARS-CoV-2 research [1].

Natural Products

Punicalagin
T3921
Synonym:
Target: SARS-CoV, HBV
Viscidulin III
TN2302
Synonym: Ganhuangenin
Target: Glucosidase
(25S)-Antcin B
T80010
Synonym:
Target: SARS-CoV

Recombinant Proteins

Species：
SARS-CoV-2 (20)
SARS (3)
2019-nCoV (1)
Expression System：
E. coli (23)
Baculovirus-Insect Cells (1)
Tag：
No Tag (14)
Tag Free (4)
C-6His (1)
C-His (1)
His (1)
N-6His (1)
N-His-Avi (1)
None (1)
Cat No. Product Name Species Expression System
TMPY-05752 SARS-CoV-2 3CLpro/3C-like protease Protein (His) SARS-CoV-2 Baculovirus-Insect Cells
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPK-01342 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01338 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01340 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPJ-01449 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant SARS-CoV-2 E. coli
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precur...
TMPK-01347 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01337 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01335 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01344 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01346 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01341 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPJ-01448 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) 2019-nCoV E. coli
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precur...
TMPK-01339 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01343 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPY-05727 SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi) SARS-CoV-2 E. coli
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPK-01336 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01348 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01345 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant SARS-CoV-2 E. coli
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01384 SARS PLpro/papain-like protease Protein (His) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPK-01352 SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro ...
TMPY-04894 SARS-CoV (strain WH20) Plpro/papain-like protease (His) SARS E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of st...
TMPY-05682 SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His) SARS-CoV-2 E. coli
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of st...
TMPJ-01428 SARS-CoV-2 NSP8 Protein (His) SARS-CoV-2 E. coli
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are...
TMPJ-01431 SARS-CoV-2 Papain-Like Protease Protein SARS-CoV-2 E. coli
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a pap...
SARS-CoV-2 3CLpro/3C-like protease Protein (His)
TMPY-05752
Species: SARS-CoV-2
Expression System: Baculovirus-Insect Cells
3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant
TMPK-01342
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant
TMPK-01338
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant
TMPK-01340
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant
TMPJ-01449
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant
TMPK-01347
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant
TMPK-01337
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant
TMPK-01335
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant
TMPK-01344
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant
TMPK-01346
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant
TMPK-01341
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)
TMPJ-01448
Species: 2019-nCoV
Expression System: E. coli
3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant
TMPK-01339
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant
TMPK-01343
Species: SARS-CoV-2
Expression System: E. coli
SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)
TMPY-05727
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant
TMPK-01336
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)
TMPK-01348
Species: SARS-CoV-2
Expression System: E. coli
3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant
TMPK-01345
Species: SARS-CoV-2
Expression System: E. coli
SARS PLpro/papain-like protease Protein (His)
TMPK-01384
Species: SARS
Expression System: E. coli
SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)
TMPK-01352
Species: SARS
Expression System: E. coli
SARS-CoV (strain WH20) Plpro/papain-like protease (His)
TMPY-04894
Species: SARS
Expression System: E. coli
SARS-CoV-2 Plpro/papain-like protease Protein (aa 1564-1880, His)
TMPY-05682
Species: SARS-CoV-2
Expression System: E. coli
SARS-CoV-2 NSP8 Protein (His)
TMPJ-01428
Species: SARS-CoV-2
Expression System: E. coli
SARS-CoV-2 Papain-Like Protease Protein
TMPJ-01431
Species: SARS-CoV-2
Expression System: E. coli
Cat No. Product Name
L1710 Anti-COVID-19 Compound Library

1160 compounds
A unique collection of 1160 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents；

Libraries

Anti-COVID-19 Compound Library
L1710
Compounds: 1160
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