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G3335 Acetate

Name: G3335 Acetate
Brand: TargetMol
SKU: T21598L
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21598L

Alias G3335 Acetate (36099-95-3 free base)

G3335 Acetate was discovered to be a novel PPARgamma antagonist.

G3335 Acetate

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Purity: 99.75%

Catalog No. T21598LAlias G3335 Acetate (36099-95-3 free base)

G3335 Acetate was discovered to be a novel PPARgamma antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$75	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$192	In Stock	In Stock
100 mg	$287	In Stock	In Stock
200 mg	$431	In Stock	In Stock
500 mg	$713	-	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	G3335 Acetate was discovered to be a novel PPARgamma antagonist.
Targets&IC50	PPARγ:8.67 μM(kd), PPARγ:8.34 μM(kd)
In vitro	G3335 exhibits a highly specific binding affinity against PPARgamma (K(D) = 8.34 microM) and is able to block rosiglitazone, a potent PPARgamma agonist, in the stimulation of the interaction between the PPARgamma ligand-binding domain (LBD) and RXRalpha-LBD. Yeast two-hybrid assays demonstrated that G3335 exhibits strong antagonistic activity (IC50 = 8.67 microM) in perturbing rosiglitazone in the promotion of the PPARgamma-LBD-CBP interaction.
Synonyms	G3335 Acetate (36099-95-3 free base)

Chemical Properties

Molecular Weight	393.39
Formula	C₁₈H₂₃N₃O₇
Smiles	OC(CC[C@H](NC([C@H](CC1=CNC2=C1C=CC=C2)N)=O)C(O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	H-Trp-Glu-OH
Sequence Short	WE

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (139.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5420 mL	12.7100 mL	25.4201 mL	127.1003 mL
5 mM	0.5084 mL	2.5420 mL	5.0840 mL	25.4201 mL
10 mM	0.2542 mL	1.2710 mL	2.5420 mL	12.7100 mL
20 mM	0.1271 mL	0.6355 mL	1.2710 mL	6.3550 mL
50 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5420 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2710 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc