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G3335 Acetate

Name: G3335 Acetate
Brand: TargetMol
SKU: T21598L
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21598L

Alias G3335 Acetate (36099-95-3 free base)

G3335 Acetate was discovered to be a novel PPARgamma antagonist.

G3335 Acetate

🥰Excellent

Purity: 99.75%

Catalog No. T21598LAlias G3335 Acetate (36099-95-3 free base)

G3335 Acetate was discovered to be a novel PPARgamma antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$75	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$192	In Stock	In Stock
100 mg	$287	In Stock	In Stock
200 mg	$431	In Stock	In Stock
500 mg	$713	-	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.75%

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	G3335 Acetate was discovered to be a novel PPARgamma antagonist.
Targets&IC50	PPARγ:8.34 μM(kd), PPARγ:8.67 μM(kd)
In vitro	G3335 exhibits a highly specific binding affinity against PPARgamma (K(D) = 8.34 microM) and is able to block rosiglitazone, a potent PPARgamma agonist, in the stimulation of the interaction between the PPARgamma ligand-binding domain (LBD) and RXRalpha-LBD. Yeast two-hybrid assays demonstrated that G3335 exhibits strong antagonistic activity (IC50 = 8.67 microM) in perturbing rosiglitazone in the promotion of the PPARgamma-LBD-CBP interaction.
Synonyms	G3335 Acetate (36099-95-3 free base)

Chemical Properties

Molecular Weight	393.39
Formula	C₁₈H₂₃N₃O₇
Smiles	OC(CC[C@H](NC([C@H](CC1=CNC2=C1C=CC=C2)N)=O)C(O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	H-Trp-Glu-OH
Sequence Short	WE

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (139.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5420 mL	12.7100 mL	25.4201 mL	127.1003 mL
5 mM	0.5084 mL	2.5420 mL	5.0840 mL	25.4201 mL
10 mM	0.2542 mL	1.2710 mL	2.5420 mL	12.7100 mL
20 mM	0.1271 mL	0.6355 mL	1.2710 mL	6.3550 mL
50 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5420 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2710 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc