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PROTAC IRAK4 degrader-3
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Catalog No. T39920Cas No. 2374122-43-5
Alias PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).
PROTAC IRAK4 degrader-3
😃Good
Catalog No. T39920Alias PROTAC IRAK4 degrader-3Cas No. 2374122-43-5
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 mg | Inquiry | Backorder | |
| 500 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL). |
| In vitro | PROTAC IRAK4 degrader-3, within a concentration range of 0.01 to 10 μM over 2 hours in PBMCs, induces proteasome-dependent degradation. An increased dosage range up to 100 μM for 18 hours in the same cell type effectively inhibits IL-6 secretion. Western Blot Analysis further confirms that the degradation of IRAK4 by PROTAC occurs in a proteasome-dependent manner within the tested concentration and time frame[1]. |
| Synonyms | PROTAC IRAK4 degrader-3 |
| Molecular Weight | 1086.3 |
| Formula | C57H68FN11O8S |
| Cas No. | 2374122-43-5 |
| Relative Density. | 1.40 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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