PROTAC IRAK4 degrader-3

Name: PROTAC IRAK4 degrader-3
Brand: TargetMol
SKU: T39920
Rating: 4.5 (1 reviews)

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Catalog No. T39920Cas No. 2374122-43-5

Alias PROTAC IRAK4 degrader-3

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).

PROTAC IRAK4 degrader-3

😃Good

Catalog No. T39920Alias PROTAC IRAK4 degrader-3Cas No. 2374122-43-5

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).
In vitro	PROTAC IRAK4 degrader-3, within a concentration range of 0.01 to 10 μM over 2 hours in PBMCs, induces proteasome-dependent degradation. An increased dosage range up to 100 μM for 18 hours in the same cell type effectively inhibits IL-6 secretion. Western Blot Analysis further confirms that the degradation of IRAK4 by PROTAC occurs in a proteasome-dependent manner within the tested concentration and time frame[1].
Synonyms	PROTAC IRAK4 degrader-3

Chemical Properties

Molecular Weight	1086.3
Formula	C₅₇H₆₈FN₁₁O₈S
Cas No.	2374122-43-5
Smiles	CC[C@H]1[C@@H](COc2ncc(C#CCN3CCC4(CC3)CCN(CC4)c3ncc(cn3)C(=O)N[C@@H](C(=O)N3C[C@@H](O)C[C@@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)c3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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