Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
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Description | PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau. |
In vitro | PROTAC IRAK4 degrader-3, within a concentration range of 0.01 to 10 μM over 2 hours in PBMCs, induces proteasome-dependent degradation. An increased dosage range up to 100 μM for 18 hours in the same cell type effectively inhibits IL-6 secretion. Western Blot Analysis further confirms that the degradation of IRAK4 by PROTAC occurs in a proteasome-dependent manner within the tested concentration and time frame[1]. |
Synonyms | PROTAC IRAK4 degrader-3 |
Molecular Weight | 1086.3 |
Formula | C57H68FN11O8S |
CAS No. | 2374122-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PROTAC IRAK4 degrader-3 2374122-43-5 PROTAC IRAK-4 degrader-3 PROTAC IRAK4 degrader3 PROTAC IRAK4 degrader 3 inhibitor inhibit