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LCKLSL acetate

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Catalog No. TP2482
Alias LCKLSL acetate(533902-29-3 free base)

LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.

LCKLSL acetate
Other Forms of LCKLSL acetate:

LCKLSL acetate

😃Good
Catalog No. TP2482Alias LCKLSL acetate(533902-29-3 free base)
LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$112BackorderBackorder
5 mg$227BackorderBackorder
10 mg$412BackorderBackorder
25 mg$686BackorderBackorder
50 mg$977BackorderBackorder
100 mg$1,320BackorderBackorder
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
In vitro
LCKLSL acetate (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions in human retinal microvascular endothelial cells (RMVECs)[1].
In vivo
In chicken chorioallantoic membrane and murine Matrigel plug assays, LCKLSL acetate significantly decreased the vascular length. LCKLSL acetate(5 μg/mL) significantly decreased the number of vascular branches, junctions and end-points[1].
SynonymsLCKLSL acetate(533902-29-3 free base)
Chemical Properties
Molecular Weight735.93
FormulaC32H61N7O10S
SmilesCC(O)=O.CC(C)C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CS)NC([C@H](CC(C)C)N)=O)=O)=O)=O)=O
Relative Density.no data available
ColorWhite
AppearanceSolid
SequenceLeu-Cys-Lys-Leu-Ser-Leu
Sequence ShortLCKLSL
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 10 mg/mL (13.59 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.3588 mL6.7941 mL13.5882 mL67.9412 mL
5 mM0.2718 mL1.3588 mL2.7176 mL13.5882 mL
10 mM0.1359 mL0.6794 mL1.3588 mL6.7941 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

LCKLSL acetateLCKLSL AcetateAnnexinAAnnexin A2Annexin A
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