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HNMPA-(AM)3

Name: HNMPA-(AM)3
Brand: TargetMol
SKU: T36584
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36584Cas No. 120944-03-8

HNMPA-(AM)3 inhibits activation of ERK phosphorylation and stimulation of ecdysteroid production by prothyrotropin (PTTH). Furthermore, HNMPA-(AM)3 had inhibitory effects on ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50=14.2 μM and 200 μM, in mosquitoes and mammals, respectively).

HNMPA-(AM)3

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Purity: 97.22%

Catalog No. T36584Cas No. 120944-03-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.22%

Resource Download

COA HNMR MS HPLC

Product Introduction

Bioactivity

Description	HNMPA-(AM)3 inhibits activation of ERK phosphorylation and stimulation of ecdysteroid production by prothyrotropin (PTTH). Furthermore, HNMPA-(AM)3 had inhibitory effects on ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50=14.2 μM and 200 μM, in mosquitoes and mammals, respectively).
Targets&IC50	insulin receptor (mosquito):200 μM, insulin receptor (mammalian):14.2 μM, ecdysteroid production:14.2 μM

Chemical Properties

Molecular Weight	454.36
Formula	C₂₀H₂₃O₁₀P
Cas No.	120944-03-8
Smiles	O=C(OCOC(C=1C=CC=2C=CC=CC2C1)P(=O)(OCOC(=O)C)OCOC(=O)C)C
Relative Density.	1.325 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 25 mg/mL (55.02 mM), Sonication is recommended.

DMF: 5 mg/mL (11 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL (2.2 mM), Sonication is recommended.

DMSO: 80 mg/mL (176.07 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2009 mL	11.0045 mL	22.0090 mL	110.0449 mL

DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4402 mL	2.2009 mL	4.4018 mL	22.0090 mL
10 mM	0.2201 mL	1.1004 mL	2.2009 mL	11.0045 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1100 mL	0.5502 mL	1.1004 mL	5.5022 mL
50 mM	0.0440 mL	0.2201 mL	0.4402 mL	2.2009 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0220 mL	0.1100 mL	0.2201 mL	1.1004 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc