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HNMPA-(AM)3

Catalog No. T36584 CAS 120944-03-8

HNMPA-(AM)3 inhibits activation of ERK phosphorylation and stimulation of ecdysteroid production by prothyrotropin (PTTH). Furthermore, HNMPA-(AM)3 had inhibitory effects on ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50=14.2 μM and 200 μM, in mosquitoes and mammals, respectively).

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HNMPA-(AM)3, CAS 120944-03-8

Pack Size	Availability	Price/USD	Quantity
440uL (2mg in 10mM DMSO)	In stock	$ 197.00

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Purity: 97.22%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HNMPA-(AM)3 inhibits activation of ERK phosphorylation and stimulation of ecdysteroid production by prothyrotropin (PTTH). Furthermore, HNMPA-(AM)3 had inhibitory effects on ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50=14.2 μM and 200 μM, in mosquitoes and mammals, respectively).
Targets&IC50	ecdysteroid production:14.2 μM, insulin receptor (mammalian):14.2 μM, insulin receptor (mosquito):200 μM

Molecular Weight	454.36
Formula	C20H23O10P
CAS No.	120944-03-8

Storage

keep away from direct sunlight,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 25 mg/mL

DMF: 5 mg/mL(11.00 mM), Sonication is recommended.

PBS (pH 7.2): 1 mg/mL

DMSO: 80 mg/mL(176.07 mM), Sonication is recommended.

References and Literature

1. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca2+/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101. 2. Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60.

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Keywords

HNMPA-(AM)3 120944-03-8 Tyrosine Kinase/Adaptors Tyrosine Kinases HNMPA(AM)3 HNMPA (AM)3 inhibitor inhibit

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