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3-TERT-BUTYL-4-HYDROXYANISOLE

Name: 3-TERT-BUTYL-4-HYDROXYANISOLE
Brand: TargetMol
SKU: T5367
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5367Cas No. 121-00-6

3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.

3-TERT-BUTYL-4-HYDROXYANISOLE

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Purity: 99.65%

Catalog No. T5367Cas No. 121-00-6

3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$30	In Stock	In Stock
2 g	$39	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

3-TERT-BUTYL-4-HYDROXYANISOLE AI Summary

3-TERT-BUTYL-4-HYDROXYANISOLE exhibits a comprehensive range of bioactivities. It demonstrates strong antioxidant activity, as indicated by its 92.6% DPPH radical scavenging activity after 30 minutes at a concentration of 0.5 mM and an IC50 of 19000.0 nM in UV-visible spectrophotometry assays. It also shows potential antineoplastic effects by decreasing tumor incidence in benzo[alpha]pyrene-induced ICR/Ha mouse forestomachs with a tumor growth inhibition (TGI) of 50.0% at 5 mg/kg, although it is associated with some toxicity observed through decreased diet intake and body weight in mice. Moreover, 3-TERT-BUTYL-4-HYDROXYANISOLE exhibits antiviral activity against SARS-CoV-2, with notable inhibition of cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentrations as evidenced by high content imaging, and an inhibition rate of the 3CL-Pro protease by 12.26% at 20 µM in FRET-based assays. The compound also shows significant inhibition in various biochemical assays, including the inhibition of Aldehyde Dehydrogenase 1, Lipid Storage Modulators, Human alpha-Glucosidase, Histone Lysine Methyltransferase G9a, Marburg Virus entry, and the cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2). Additionally, it acts as an agonist of the antioxidant response element (ARE) signaling pathway and a small molecule activator of the human pregnane X receptor (PXR) signaling pathway. Enzyme assays reveal that 3-TERT-BUTYL-4-HYDROXYANISOLE displays specific activity with human recombinant UGT1A9 but not with UGT1A6, and it exhibits inhibitory activity against the human HDAC6 enzyme..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.

Chemical Properties

Molecular Weight	180.24
Formula	C₁₁H₁₆O₂
Cas No.	121-00-6
Smiles	COC1=CC(=C(O)C=C1)C(C)(C)C
Relative Density.	1.009 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (249.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5482 mL	27.7408 mL	55.4816 mL	277.4079 mL
5 mM	1.1096 mL	5.5482 mL	11.0963 mL	55.4816 mL
10 mM	0.5548 mL	2.7741 mL	5.5482 mL	27.7408 mL
20 mM	0.2774 mL	1.3870 mL	2.7741 mL	13.8704 mL
50 mM	0.1110 mL	0.5548 mL	1.1096 mL	5.5482 mL
100 mM	0.0555 mL	0.2774 mL	0.5548 mL	2.7741 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc