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3-pyridine toxoflavin

Name: 3-pyridine toxoflavin
Brand: TargetMol
SKU: T67738
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67738Cas No. 32502-20-8

3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.

3-pyridine toxoflavin

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Purity: 99.93%

Catalog No. T67738Cas No. 32502-20-8

3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	-	In Stock
5 mg	$449	-	In Stock
10 mg	$659	-	In Stock
25 mg	$987	-	In Stock
50 mg	$1,390	-	In Stock
100 mg	$1,880	-	In Stock
500 mg	$3,780	-	In Stock
1 mL x 10 mM (in DMSO)	$397	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.93%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

3-pyridine toxoflavin AI Summary

3-pyridine toxoflavin has demonstrated significant bioactivity across multiple assays and various biological targets. It exhibits inhibitory potency against Cruzain, Nrf2, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), Giardia lamblia, TGF-β, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and Vaccinia Orthopoxvirus, with varying potencies ranging from 1155.4 nM to 19952.6 nM. Additionally, it inhibits KDM4C with an IC50 of 19.0 nM. The compound also shows cytotoxicity against human THLE cells with EC50 values of 3100.0 nM after 72 hours, 5800.0 nM after 24 hours, and 11700.0 nM after 4 hours. It induces reactive oxygen species (ROS) generation, specifically H2O2, with an EC50 of 1000.0 nM after 60 minutes. Further bioactivity includes antiproliferative effects on human HepG2 cells (IC50 of 1800.0 nM) and A549 cells (IC50 of 4300.0 nM). The compound has a cell permeability rate of 13.4 x 10^-6 cm/s, intrinsic clearance in mouse liver microsomes at 11.6 µL/min, and displays a high basolateral to apical efflux ratio, indicating efficient cellular permeability and potential for high-throughput applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

3-pyridine toxoflavin is a potent KDM4C inhibitor, IC50=19nM.

Chemical Properties

Molecular Weight	270.25
Formula	C₁₂H₁₀N₆O₂
Cas No.	32502-20-8
Smiles	O=C1C=2C(N(C)N=C(N2)C=3C=CN=CC3)=NC(=O)N1C
Relative Density.	1.55 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (166.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7003 mL	18.5014 mL	37.0028 mL	185.0139 mL
5 mM	0.7401 mL	3.7003 mL	7.4006 mL	37.0028 mL
10 mM	0.3700 mL	1.8501 mL	3.7003 mL	18.5014 mL
20 mM	0.1850 mL	0.9251 mL	1.8501 mL	9.2507 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7003 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8501 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc