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LY3027788
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Catalog No. T38792Cas No. 1377615-76-3
Alias LY3027788
LY3027788, a diester analog of LY3020371 and an mGlu2/3 receptor antagonist, is a highly potent, orally active prodrug of LY3020371 with notable antidepressant efficacy.
LY3027788
Copy Product Info😃Good
Catalog No. T38792Alias LY3027788Cas No. 1377615-76-3
LY3027788, a diester analog of LY3020371 and an mGlu2/3 receptor antagonist, is a highly potent, orally active prodrug of LY3020371 with notable antidepressant efficacy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | LY3027788, a diester analog of LY3020371 and an mGlu2/3 receptor antagonist, is a highly potent, orally active prodrug of LY3020371 with notable antidepressant efficacy. |
| In vivo | LY3027788 (4.8-27 mg/kg; a single p.o.) significantly decreases immobility times in the forced-swim test, enhances the locomotor stimulant effects of quinpirole at 16 mg/kg in mice, and dose-dependently increases wake time in rats without causing rebound hypersomnolence. It leads to the rapid and dose-proportionate appearance of LY3020371 in plasma of both mice (4.8-27 mg/kg) and rats (3-30 mg/kg). In male Sprague-Dawley mice (20-25 g), a single p.o. dose (4.8, 16, 27 mg/kg; 60 minutes prior to testing) is potent and efficacious with a minimal effective dose of 16 mg/kg in the forced-swim assay and an ED 60 of 8.2 mg/kg. |
| Synonyms | LY3027788 |
| Molecular Weight | 591.58 |
| Formula | C25H31F2NO11S |
| Cas No. | 1377615-76-3 |
| Smiles | [H][C@]12[C@H](C(=O)OCOC(=O)OC(C)C)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(F)c1)[C@H]2O)C(=O)OCOC(=O)OC(C)C |
| Relative Density. | 1.42 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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