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3'-Sialyllactose sodium

Name: 3'-Sialyllactose sodium
Brand: TargetMol
SKU: T35707
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35707Cas No. 128596-80-5

Alias 3'-SL sodium

3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.

3'-Sialyllactose sodium

🥰Excellent

Catalog No. T35707Alias 3'-SL sodiumCas No. 128596-80-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$55	In Stock	In Stock
25 mg	$92	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.
In vitro	For 24-36 hours at concentrations ranging from 0 to 250 μM, 3'-Sialyllactose sodium promotes and restores Col2a1 synthesis, accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].In chondrocytes, 3'-Sialyllactose sodium (0-250 μM; 24 hours) activates the expression of Sox9 and inhibits NF-κB activation[3].In the presence or absence of metabolic activation, 3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect and does not exhibit evident growth inhibition and deposition in all strains[1].At a concentration of 1250 μg/mL, 3'-Sialyllactose sodium induces no chromosomal aberrations and demonstrates a non-clastogenic effect in either the presence or absence of metabolic activation[1].
In vivo	For 6 weeks, mice were orally administered 3'-Sialyllactose sodium at doses of 10-100 mg/kg three times a week, protecting them against cartilage destruction from osteoarthritis[3].A single oral administration of 3'-Sialyllactose sodium at doses of 500, 1000, and 2000 mg/kg induces no micronuclei in the bone marrow cells of mice[1].In male and female beagle dogs, the maximum tolerance dose (MTD) of 3'-Sialyllactose sodium, given orally at doses ranging from 500 to 1000 to 2000 mg/kg at 4-day intervals, is greater than 2000 mg/kg[3].3'-Sialyllactose sodium demonstrates a lethal dose (LD50) above 20 g/kg bw, which is the highest tested dose[1].
Synonyms	3'-SL sodium

Chemical Properties

Molecular Weight	655.53
Formula	C₂₃H₃₈NNaO₁₉
Cas No.	128596-80-5
Smiles	[Na+].[H][C@@](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@]([H])(O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]1O)([C@H](O)CO)[C@H](O)[C@@H](O)C=O

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (7.63 mM), Sonication is recommended.

H2O: 100 mg/mL (152.55 mM), Sonication is recommended.

PBS (pH 7.2): 10 mg/mL (15.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO/PBS (pH 7.2)/H2O

	1mg	5mg	10mg	50mg
1 mM	1.5255 mL	7.6274 mL	15.2548 mL	76.2742 mL
5 mM	0.3051 mL	1.5255 mL	3.0510 mL	15.2548 mL

PBS (pH 7.2)/H2O

	1mg	5mg	10mg	50mg
10 mM	0.1525 mL	0.7627 mL	1.5255 mL	7.6274 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0763 mL	0.3814 mL	0.7627 mL	3.8137 mL
50 mM	0.0305 mL	0.1525 mL	0.3051 mL	1.5255 mL
100 mM	0.0153 mL	0.0763 mL	0.1525 mL	0.7627 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc