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3'-Sialyllactose sodium

Catalog No. T35707 CAS 128596-80-5

Synonyms: 3'-SL sodium

3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.

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3'-Sialyllactose sodium Chemical Structure

3'-Sialyllactose sodium, CAS 128596-80-5

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5 mg	In stock	$ 30.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 92.00

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Purity: 100%

Biological Description

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Description	3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.
In vitro	For 24-36 hours at concentrations ranging from 0 to 250 μM, 3'-Sialyllactose sodium promotes and restores Col2a1 synthesis, accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].In chondrocytes, 3'-Sialyllactose sodium (0-250 μM; 24 hours) activates the expression of Sox9 and inhibits NF-κB activation[3].In the presence or absence of metabolic activation, 3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect and does not exhibit evident growth inhibition and deposition in all strains[1].At a concentration of 1250 μg/mL, 3'-Sialyllactose sodium induces no chromosomal aberrations and demonstrates a non-clastogenic effect in either the presence or absence of metabolic activation[1].
In vivo	For 6 weeks, mice were orally administered 3'-Sialyllactose sodium at doses of 10-100 mg/kg three times a week, protecting them against cartilage destruction from osteoarthritis[3].A single oral administration of 3'-Sialyllactose sodium at doses of 500, 1000, and 2000 mg/kg induces no micronuclei in the bone marrow cells of mice[1].In male and female beagle dogs, the maximum tolerance dose (MTD) of 3'-Sialyllactose sodium, given orally at doses ranging from 500 to 1000 to 2000 mg/kg at 4-day intervals, is greater than 2000 mg/kg[3].3'-Sialyllactose sodium demonstrates a lethal dose (LD50) above 20 g/kg bw, which is the highest tested dose[1].

Synonyms	3'-SL sodium
Molecular Weight	655.53
Formula	C23H38NNaO19
CAS No.	128596-80-5

Storage

keep away from moisture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL

H2O: 100 mg/mL (152.54 mM), Sonication is recommended.

PBS (pH 7.2): 10 mg/mL

References and Literature

1. Kim D, et al. Toxicological evaluation of 3'-sialyllactose sodium salt. Regul Toxicol Pharmacol. 2018 Apr;94:83-90. 2. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603. 3. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library

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Keywords

3'-Sialyllactose sodium 128596-80-5 NF-Κb NF-κB 3' Sialyllactose (sodium salt) 3'Sialyllactose (sodium salt) 3'-Sialyllactose 3'-SL sodium inhibitor inhibit

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