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Methyl methanesulfonate

Name: Methyl methanesulfonate
Brand: TargetMol
SKU: T9985
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9985Cas No. 66-27-3

Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and replication disorders.

Methyl methanesulfonate

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Purity: 99.69%

Catalog No. T9985Cas No. 66-27-3

Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and replication disorders.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock

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Purity:99.69%

Appearance:Liquid

Color:Transparent

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COA HNMR

Product Introduction

Methyl methanesulfonate AI Summary

Methyl methanesulfonate exhibits a range of bioactivities. It shows dose-dependent cytotoxicity against L-1210 leukemia cells and human MCF7 cells, with EC50 values of 2750000.0 nM after 16 hours for the latter. In cancer therapeutics, it inhibits growth of various human tumor cell lines with a GI50 potency of 1999.86 nM. Functionally, it acts as an agonist for the Thyroid Stimulating Hormone Receptor and the antioxidant response element (ARE) signaling pathway and as an inhibitor of Ubiquitin-specific Protease USP2a. Methyl methanesulfonate also demonstrates genotoxic effects in bacterial assays, showing significant genotoxicity in Escherichia coli WP2uvrA and Salmonella typhimurium strains TA1535 and TA100. It exhibits DNA binding affinity, inducing specific DNA adducts (3-MeA and 7-MeG) with higher activity towards 7-MeG. Notably, it inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells. In vivo, Methyl methanesulfonate extends the mean life span of mice infected with Trypanosoma rhodesiense at a dose of 0.2 mmol/kg. Additionally, it shows significant bioactivity impacting liver and kidney function, electrolyte balance, and blood cell counts, suggesting broader systemic effects. Also, its DNA protective properties are evidenced by reversing ionizing radiation-induced DNA double-strand breaks. Overall, the multi-faceted bioactivity profile of Methyl methanesulfonate highlights its potential for therapeutic applications and systemic biological effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Methyl methanesulfonate is a DNA alkylator that modifies adenine (3-methyladenine) and guanine (7-methyladenine) respectively, resulting in base mismatch and replication disorders.

Chemical Properties

Molecular Weight	110.13
Formula	C₂H₆O₃S
Cas No.	66-27-3
Smiles	O=S(=O)(OC)C

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (544.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.0802 mL	45.4009 mL	90.8018 mL	454.0089 mL
5 mM	1.8160 mL	9.0802 mL	18.1604 mL	90.8018 mL
10 mM	0.9080 mL	4.5401 mL	9.0802 mL	45.4009 mL
20 mM	0.4540 mL	2.2700 mL	4.5401 mL	22.7004 mL
50 mM	0.1816 mL	0.9080 mL	1.8160 mL	9.0802 mL
100 mM	0.0908 mL	0.4540 mL	0.9080 mL	4.5401 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc