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HaloPROTAC3

Name: HaloPROTAC3
Brand: TargetMol
SKU: T32043
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32043Cas No. 1799506-07-2

Alias HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3

HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.

HaloPROTAC3

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Purity: 95.44%

Catalog No. T32043Alias HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3Cas No. 1799506-07-2

HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.

Pack Size	Price	Availability
1 mg	$112	In Stock
5 mg	$278	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock

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Batch Information

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Purity:95.44%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
In vitro	HaloPROTAC 3 is an efficacious GFP-HaloTag7 degrader (DC50 = 19 nM). HaloPROTAC 3(625 nM) induces 90 % degradation of GFP-Halotag. HaloPROTAC 3 binds to VHL with an IC50 of 0.54 μM[1].
Synonyms	HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3

Chemical Properties

Molecular Weight	799.42
Formula	C₄₁H₅₅ClN₄O₈S
Cas No.	1799506-07-2
Smiles	[C@@H](C(=O)N1[C@H](C(NCC2=C(OCCOCCOCCOCCCCCCCl)C=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)(C(C)C)N4C(=O)C=5C(C4)=CC=CC5
Relative Density.	1.250 g/cm3 (Predicted)
Color	White
Appearance	Viscous

Storage & Solubility Information

Storage

keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.14 mg/mL (104 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2509 mL	6.2545 mL	12.5091 mL	62.5453 mL
5 mM	0.2502 mL	1.2509 mL	2.5018 mL	12.5091 mL
10 mM	0.1251 mL	0.6255 mL	1.2509 mL	6.2545 mL
20 mM	0.0625 mL	0.3127 mL	0.6255 mL	3.1273 mL
50 mM	0.0250 mL	0.1251 mL	0.2502 mL	1.2509 mL
100 mM	0.0125 mL	0.0625 mL	0.1251 mL	0.6255 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc