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HaloPROTAC3

Name: HaloPROTAC3
Brand: TargetMol
SKU: T32043
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32043Cas No. 1799506-07-2

Alias HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3

HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.

HaloPROTAC3

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Purity: 99.76%

Catalog No. T32043Alias HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3Cas No. 1799506-07-2

HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$112	In Stock	In Stock
5 mg	$278	In Stock	In Stock
10 mg	$455	-	In Stock
25 mg	$753	-	In Stock
50 mg	$1,060	-	In Stock
100 mg	$1,430	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
In vitro	HaloPROTAC 3 is an efficacious GFP-HaloTag7 degrader (DC50 = 19 nM). HaloPROTAC 3(625 nM) induces 90 % degradation of GFP-Halotag. HaloPROTAC 3 binds to VHL with an IC50 of 0.54 μM[1].
Synonyms	HaloPROTAC-3, HaloPROTAC 3, Halo PROTAC-3

Chemical Properties

Molecular Weight	799.42
Formula	C₄₁H₅₅ClN₄O₈S
Cas No.	1799506-07-2
Smiles	[C@@H](C(=O)N1[C@H](C(NCC2=C(OCCOCCOCCOCCCCCCCl)C=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)(C(C)C)N4C(=O)C=5C(C4)=CC=CC5
Relative Density.	1.250 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.14 mg/mL (104 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2509 mL	6.2545 mL	12.5091 mL	62.5453 mL
5 mM	0.2502 mL	1.2509 mL	2.5018 mL	12.5091 mL
10 mM	0.1251 mL	0.6255 mL	1.2509 mL	6.2545 mL
20 mM	0.0625 mL	0.3127 mL	0.6255 mL	3.1273 mL
50 mM	0.0250 mL	0.1251 mL	0.2502 mL	1.2509 mL
100 mM	0.0125 mL	0.0625 mL	0.1251 mL	0.6255 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc