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ami

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    6345
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
AMI-1 free acid
T22239134-47-4
AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with inhibitory concentration 50 (IC50) values of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It achieves its PRMTs inhibitory activity by obstructing peptide-substrate binding [1].
  • $40
In Stock
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QTY
AMI-1
T235220324-87-2
AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0 8.8 μM, for yeast Hmt1p, and human PRMT1).
  • $42
In Stock
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AMI-408
T20039178866-14-5
AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.
  • $1,520
4-6 weeks
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AMI-193
Spiramide, Espiramida
T21855510-74-7
AMI-193 (Spiramide) is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.
  • $38
In Stock
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5-Aminosalicylic Acid
Mesalazine, Mesalamine, 5-ASA
T064689-57-6
5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
  • $45
In Stock
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TargetMol | Inhibitor Hot
Cyclophosphamide
T0707L50-18-0
Cyclophosphamide is an alkylating agent type of anti-tumor drug, and its main target is DNA. Cyclophosphamide inhibits the proliferation of tumor cells by undergoing alkylation reactions with DNA, interfering with the replication and transcription processes of DNA.
  • $35
In Stock
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TargetMol | Inhibitor Hot
Niclosamide
Niclocide, BAY2353
T071150-65-7
Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
  • $39
In Stock
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TargetMol | Inhibitor Hot
Penicillamine
D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, Artamine
T098352-67-5
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.
  • $42
In Stock
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TargetMol | Inhibitor Hot
Deferoxamine
Desferrioxamine B, Deferoxamine B
T12435870-51-9
Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine can be used to reduce the accumulation and deposition of iron in tissues. Deferoxamine can improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. It has antioxidant, anti-proliferation and anti-tumor activities, and can induce the production of HIF-1α, apoptosis and autophagy in cancer cells. It can be used to treat acute iron toxicity and COVID-19 related diseases.
  • $61
In Stock
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TargetMol | Inhibitor Hot
Deferoxamine Mesylate
DFOM, Desferrioxamine B mesylate
T1637138-14-7
Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.
  • $58
In Stock
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TargetMol | Inhibitor Hot
Suramin Sodium Salt
Suramin hexasodium salt, NF-060, BAY-205
T2160129-46-4
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
  • $35
In Stock
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TargetMol | Inhibitor Hot
Amifostine
Ethyol, WR2721, Gammaphos
T328920537-88-6
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
  • $30
In Stock
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TargetMol | Inhibitor Hot
Trimethylamine N-oxide
T412451184-78-7
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite derived from dietary choline, betaine, and carnitine. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation through the activation of the TGF-β/Smad2 signaling pathway. TMAO is commonly used to induce cardiac fibrosis models.
  • $29
In Stock
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TargetMol | Inhibitor Hot
Enzalutamide
MDV3100
T6002915087-33-1
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP) that activates autophagy, exhibits antitumor activity, and is commonly used in treating desmoplasia-resistant prostate cancer.
  • $40
In Stock
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TargetMol | Inhibitor Hot
Phos-tag Acrylamide AAL-107
T67772871839-54-2In house
Phos-tag Acrylamide AAL-107 is a polyacrylamide-conjugated phosphate-binding tag that can be used as a tool for visualizing phosphorylated proteins.
  • $257
In Stock
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TargetMol | Inhibitor Hot
Adhesamine
T73094462605-73-8
Adhesamine, a dumbbell-shaped molecule, plays a crucial role in activating the MAPK FAK pathway, thus promoting mammalian cell adhesion and growth. Additionally, it accelerates the differentiation and enhances the survival of mice hippocampal neurons in primary culture.
  • $1,520
6-8 weeks
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TargetMol | Inhibitor Hot
Amivantamab
JNJ-61186372, JNJ61186372, JNJ 61186372
T771102171511-58-1
Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer.
  • $289
In Stock
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TargetMol | Inhibitor Hot
Rocaglamide
Rocaglamide A, Roc-A
TQ013184573-16-0
Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.
  • $166
In Stock
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TargetMol | Inhibitor Hot
Antihistamine-1
T103351186430-60-3In house
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM).
  • $53
In Stock
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Apyramide
T1035568483-33-0In house
Apyramide is an anti-inflammatory agent (NSAID) that acts as a prodrug of indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of COX1 and COX2.
  • $41
In Stock
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Arbutamine
GP 21213
T10364128470-16-6In house
Arbutamine (GP 21213) is a novel potent non-selective beta-adrenoceptor agonist with alpha-1-sympathomimetic activity.Arbutamine promotes cardiac stress and increases heart rate, cardiac contractility.Arbutamine can be used to study cardiac stress and coronary artery disease
  • $268
In Stock
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Autogramin-1
T104132375541-73-2In house
Autogramin-1 potently inhibits autophagy induced by mTORC1 inhibition (Rapamycin; IC50: 0.44 μM) or starvation (IC50: 0.17 μM).
  • $139
In Stock
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Dopamine D2 receptor antagonist-1
T110771055411-77-2In house
Dopamine D2 Receptor Antagonist-1 functions as a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R), demonstrating sub-millimolar affinity.
  • $55
In Stock
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Camizestrant
Estrogen receptor antagonist 2
T112372222844-89-3In house
Camizestrant (Estrogen receptor antagonist 2) is an antagonist of the estrogen receptor and can be used in studies about ER+ HER2-advanced breast cancer[1].
  • $158
In Stock
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