Fmoc-Ser(tBu)-OH is a protected serine derivative widely applied in peptide synthesis and chemical biology. Fmoc-Ser(tBu)-OH, bearing a tert-butyl-protected hydroxyl group, provides selectivity and stability during synthetic processes, enabling its use in the assembly of peptides, biomaterials, and research compounds across diverse life science applications.

Fmoc-Ser(tBu)-OH serves as an N-terminal protecting reagent applied in peptide synthesis [1]. Reported applications include: achieving cyclization steps through chemoselective serine ligation in the total synthesis of the antibiotic daptomycin [2]; preparing MUC1 (a T-cell helper peptide) via repeated pentafluorophenyl ester-mediated fragment condensation [3]; and being utilized in the linear solid-phase peptide synthesis of ubiquitin and diubiquitin [4].