Shopping Cart
- Remove All
Your shopping cart is currently empty
SKF-83566 hydrochloride
🥰Excellent
Catalog No. T8702LCas No. 164265-49-0
Alias SKF-83566 hydrochloride(99295-33-7 Free base)
SKF-83566 hydrochloride is a D1-like dopamine receptor antagonist that can cross the blood-brain barrier and is orally active. It inhibits the dopamine transporter, reduces the conditioned place preference (CPP) induced by GBP, and can be used in the study of neurological diseases.
SKF-83566 hydrochloride
🥰Excellent
Purity: 99.27%
Catalog No. T8702LAlias SKF-83566 hydrochloride(99295-33-7 Free base)Cas No. 164265-49-0
SKF-83566 hydrochloride is a D1-like dopamine receptor antagonist that can cross the blood-brain barrier and is orally active. It inhibits the dopamine transporter, reduces the conditioned place preference (CPP) induced by GBP, and can be used in the study of neurological diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $45 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $156 | In Stock | |
| 25 mg | $350 | In Stock | |
| 50 mg | $660 | In Stock |
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View MoreBatch Information
Select Batch
Purity:99.27%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | SKF-83566 hydrochloride is a D1-like dopamine receptor antagonist that can cross the blood-brain barrier and is orally active. It inhibits the dopamine transporter, reduces the conditioned place preference (CPP) induced by GBP, and can be used in the study of neurological diseases. |
| Targets&IC50 | DAT:5.7 μM |
| In vitro | SKF-83566 hydrochloride is a competitive dopamine transporter (DAT) inhibitor with an IC50 of 5.7 μM. [1] SKF-83566 hydrochloride acts on the vascular 5-HT2 receptor (Ki=11 nM). [2] |
| In vivo | Combined administration of SKF-83566 hydrochloride (0.15 mg/kg/mL) and A68930 (0.4 mg/kg/mL) prevented glutamate-based long-term enhancement (LTP) in the medial prefrontal cortex mPFC and led to long-term depression induced by high frequency stimulation (HFS). [3] |
| Synonyms | SKF-83566 hydrochloride(99295-33-7 Free base) |
| Molecular Weight | 368.69 |
| Formula | C17H19BrClNO |
| Cas No. | 164265-49-0 |
| Smiles | Cl.BrC=1C=C2C(=CC1O)C(C=3C=CC=CC3)CN(C)CC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy SKF-83566 hydrochloride | purchase SKF-83566 hydrochloride | SKF-83566 hydrochloride cost | order SKF-83566 hydrochloride | SKF-83566 hydrochloride chemical structure | SKF-83566 hydrochloride in vivo | SKF-83566 hydrochloride in vitro | SKF-83566 hydrochloride formula | SKF-83566 hydrochloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.