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Isomyosmine

Name: Isomyosmine
Brand: TargetMol
SKU: T85324
Rating: 4.5 (1 reviews)

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Catalog No. T85324Cas No. 53844-46-5

Alias Isomyosamine

Isomyosmine is an isomer of myosine that inhibits nitrate reductase, has potential antiviral activity, reduces oxidative stress, can promote plant health and increase productivity and yield. Isomyosmine inhibits the release of TNF-α and can be used to study inflammation and coronavirus infection related to oxidoreductase.

Isomyosmine

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Purity: 99.16%

Catalog No. T85324Alias IsomyosamineCas No. 53844-46-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$568	Inquiry	Inquiry
5 mg	$1,168	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.16%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Isomyosmine is an isomer of myosine that inhibits nitrate reductase, has potential antiviral activity, reduces oxidative stress, can promote plant health and increase productivity and yield. Isomyosmine inhibits the release of TNF-α and can be used to study inflammation and coronavirus infection related to oxidoreductase.
In vivo	b>METHODS: The study was conducted in a double-blind manner: subjects in each dose group (Groups 1, 2, 3, and 4) were randomly assigned to receive either Isomyosmine dose (between 150 mg and 600 mg or placebo) or placebo in a 3:1 ratio (6 active drugs: 2 placebos). RESULTS: Single daily doses of Isomyosmine of 150 mg, 300 mg, and 450 mg for 3 consecutive days and multiple daily doses of 600 mg for 6 consecutive days were safe and well tolerated in healthy subjects; within one dose group, TNF-α levels decreased in subjects treated with Isomyosmine but did not change in subjects treated with placebo; when given as a single dose, the increase in Isomyosmine exposure was dose-proportional over the dose range of 300 mg to 600 mg. Minimal accumulation of Isomyosmine was observed after 5 consecutive days of Isomyosmine 600 mg daily. [1]
Synonyms	Isomyosamine

Chemical Properties

Molecular Weight	146.19
Formula	C₉H₁₀N₂
Cas No.	53844-46-5
Smiles	N=1C=CC=C(C1)C2N=CCC2
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (171.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (13.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8404 mL	34.2021 mL	68.4041 mL	342.0207 mL
5 mM	1.3681 mL	6.8404 mL	13.6808 mL	68.4041 mL
10 mM	0.6840 mL	3.4202 mL	6.8404 mL	34.2021 mL
20 mM	0.3420 mL	1.7101 mL	3.4202 mL	17.1010 mL
50 mM	0.1368 mL	0.6840 mL	1.3681 mL	6.8404 mL
100 mM	0.0684 mL	0.3420 mL	0.6840 mL	3.4202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc