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5’-(E)-VPG Phosphoramidite

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Catalog No. TSW-01110

5’-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent designed for synthesizing biologically stable oligonucleotides. It includes a VP protecting group that facilitates 5’ end coupling with target oligonucleotide chains via solid-phase synthesis. The construction of the modified oligonucleotide is completed through oxidation and deprotection steps. This compound is particularly useful in RNAi and viral replication research.

5’-(E)-VPG Phosphoramidite

5’-(E)-VPG Phosphoramidite

😃Good
Catalog No. TSW-01110
5’-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent designed for synthesizing biologically stable oligonucleotides. It includes a VP protecting group that facilitates 5’ end coupling with target oligonucleotide chains via solid-phase synthesis. The construction of the modified oligonucleotide is completed through oxidation and deprotection steps. This compound is particularly useful in RNAi and viral replication research.
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Description
5’-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent designed for synthesizing biologically stable oligonucleotides. It includes a VP protecting group that facilitates 5’ end coupling with target oligonucleotide chains via solid-phase synthesis. The construction of the modified oligonucleotide is completed through oxidation and deprotection steps. This compound is particularly useful in RNAi and viral replication research.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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