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Noberastine

Name: Noberastine
Brand: TargetMol
SKU: T25875
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25875Cas No. 110588-56-2

Alias T25875, R-64947, R64947, R 64947

Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity.

Noberastine

🥰Excellent

Purity: 99.72%

Catalog No. T25875Alias T25875, R-64947, R64947, R 64947Cas No. 110588-56-2

Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$146	In Stock	In Stock
5 mg	$350	In Stock	In Stock
10 mg	$530	In Stock	In Stock
25 mg	$1,025	In Stock	In Stock
50 mg	$1,400	In Stock	In Stock
100 mg	$2,160	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.72%

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity.
In vivo	Noberastine (10, 20, and 30 mg; single dose; 12 healthy male volunteers) significant inhibition of histamine-induced skin wheals occurred and this effect persisted beyond 24 h. At the higher (20 and 30 mg) doses studied significant inhibition of the histamine-induced skin wheal occurred by 1 h of dosi
Synonyms	T25875, R-64947, R64947, R 64947

Chemical Properties

Molecular Weight	311.38
Formula	C₁₇H₂₁N₅O
Cas No.	110588-56-2
Smiles	C(N1C=2C(N=C1NC3CCNCC3)=CC=CN2)C=4OC(C)=CC4
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (192.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2115 mL	16.0576 mL	32.1151 mL	160.5755 mL
5 mM	0.6423 mL	3.2115 mL	6.4230 mL	32.1151 mL
10 mM	0.3212 mL	1.6058 mL	3.2115 mL	16.0576 mL
20 mM	0.1606 mL	0.8029 mL	1.6058 mL	8.0288 mL
50 mM	0.0642 mL	0.3212 mL	0.6423 mL	3.2115 mL
100 mM	0.0321 mL	0.1606 mL	0.3212 mL	1.6058 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc