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ATWLPPRAANLLMAAS

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Catalog No. TP2993Cas No. 1228447-26-4

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).

ATWLPPRAANLLMAAS

ATWLPPRAANLLMAAS

😃Good
Catalog No. TP2993Cas No. 1228447-26-4
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent antitumor capabilities. It effectively inhibits the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induces apoptosis (apoptosis).
In vitro
ATWLPPRAANLLMAAS (V3) (25-200 μM; 12-24 h) suppresses the proliferation, viability, migration, and invasion of human HCC cells (SMMC-7721, Huh-7) by inhibiting the Ras/Raf/MEK/ERK signaling pathway, though no significant effects were observed in HL-7702 cells.
In vivo
ATWLPPRAANLLMAAS (160-480 μg/kg; s.c.; once daily for 7 days) can significantly inhibit the growth of transplanted mouse sarcoma S180 and H22 liver cancer tumors in a dose-dependent manner. Additionally, ATWLPPRAANLLMAAS (200 μg/kg; s.c.; once daily for 4 weeks) suppresses the growth of human HCC xenograft tumors by downregulating angiogenesis and promoting apoptosis.
Chemical Properties
Molecular Weight1682.98
FormulaC76H123N21O20S
Cas No.1228447-26-4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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