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Vamifeport

Name: Vamifeport
Brand: TargetMol
SKU: T39520
Rating: 4.5 (1 reviews)

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Catalog No. T39520Cas No. 2095668-10-1

Alias VIT-2763

Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.

Vamifeport

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Purity: 99.91%

Catalog No. T39520Alias VIT-2763Cas No. 2095668-10-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	7-10 days	7-10 days
5 mg	$153	7-10 days	7-10 days
10 mg	$231	-	In Stock
25 mg	$377	7-10 days	7-10 days
50 mg	$546	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$168	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Appearance:Viscous

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.
In vitro	Treatment with VIT-2763 (20μM) or hepcidin (1μM) for 20 minutes, 1 hour, 3 hours, 6 hours, and 18 hours induced dose-dependent internalization and ubiquitination of iron transporters in MDCK cells[1].
In vivo	VIT-2763 (30, 100 mg/kg; orally twice daily for 36 days) restricted iron availability, ameliorating anemia and iron homeostasis dysregulation in the intermediate β-thalassemia Hbbth3/+ mouse model, improving erythropoiesis and correcting the proportion of myeloid precursors in the spleen of Hbbth3/+ mice[1].
Synonyms	VIT-2763

Chemical Properties

Molecular Weight	408.43
Formula	C₂₁H₂₁FN₆O₂
Cas No.	2095668-10-1
Smiles	Fc1cccnc1CNC(=O)c1coc(CCNCCc2nc3ccccc3[nH]2)n1

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (171.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4484 mL	12.2420 mL	24.4840 mL	122.4200 mL
5 mM	0.4897 mL	2.4484 mL	4.8968 mL	24.4840 mL
10 mM	0.2448 mL	1.2242 mL	2.4484 mL	12.2420 mL
20 mM	0.1224 mL	0.6121 mL	1.2242 mL	6.1210 mL
50 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4484 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2242 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc