Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 129.00 | |
5 mg | In stock | $ 315.00 | |
10 mg | In stock | $ 468.00 | |
25 mg | In stock | $ 768.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 381.00 |
Description | Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia. |
In vitro | Treatment with VIT-2763 (20μM) or hepcidin (1μM) for 20 minutes, 1 hour, 3 hours, 6 hours, and 18 hours induced dose-dependent internalization and ubiquitination of iron transporters in MDCK cells[1]. |
In vivo | VIT-2763 (30, 100 mg/kg; orally twice daily for 36 days) restricted iron availability, ameliorating anemia and iron homeostasis dysregulation in the intermediate β-thalassemia Hbbth3/+ mouse model. VIT-2763 not only improved erythropoiesis but also corrected the proportion of myeloid precursors in the spleen of Hbbth3/+ mice[1]. |
Synonyms | VIT-2763 |
Molecular Weight | 408.43 |
Formula | C21H21FN6O2 |
CAS No. | 2095668-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 70 mg/mL (171.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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