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Vamifeport

Name: Vamifeport
Brand: TargetMol
SKU: T39520
Rating: 4.5 (1 reviews)

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Catalog No. T39520Cas No. 2095668-10-1

Alias VIT-2763

Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.

Vamifeport

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Catalog No. T39520Alias VIT-2763Cas No. 2095668-10-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	7-10 days	7-10 days
5 mg	$162	7-10 days	7-10 days
10 mg	$243	7-10 days	7-10 days
25 mg	$397	7-10 days	7-10 days
50 mg	$575	7-10 days	7-10 days
100 mg	$786	7-10 days	7-10 days
200 mg	$1,080	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$177	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.
In vitro	Treatment with VIT-2763 (20μM) or hepcidin (1μM) for 20 minutes, 1 hour, 3 hours, 6 hours, and 18 hours induced dose-dependent internalization and ubiquitination of iron transporters in MDCK cells[1].
In vivo	VIT-2763 (30, 100 mg/kg; orally twice daily for 36 days) restricted iron availability, ameliorating anemia and iron homeostasis dysregulation in the intermediate β-thalassemia Hbbth3/+ mouse model, improving erythropoiesis and correcting the proportion of myeloid precursors in the spleen of Hbbth3/+ mice[1].
Synonyms	VIT-2763

Chemical Properties

Molecular Weight	408.43
Formula	C₂₁H₂₁FN₆O₂
Cas No.	2095668-10-1
Smiles	Fc1cccnc1CNC(=O)c1coc(CCNCCc2nc3ccccc3[nH]2)n1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (171.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4484 mL	12.2420 mL	24.4840 mL	122.4200 mL
5 mM	0.4897 mL	2.4484 mL	4.8968 mL	24.4840 mL
10 mM	0.2448 mL	1.2242 mL	2.4484 mL	12.2420 mL
20 mM	0.1224 mL	0.6121 mL	1.2242 mL	6.1210 mL
50 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4484 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2242 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc