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N-Me-aminopyrimidinone9
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Catalog No. T8444Cas No. 1356834-62-2
N-Me-aminopyrimidinone9 is a sodium channel antagonist
N-Me-aminopyrimidinone9
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Purity: 99.21%
Catalog No. T8444Cas No. 1356834-62-2
N-Me-aminopyrimidinone9 is a sodium channel antagonist
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $56 | In Stock | In Stock | |
| 5 mg | $125 | In Stock | In Stock | |
| 10 mg | $190 | In Stock | In Stock | |
| 25 mg | $313 | In Stock | In Stock | |
| 50 mg | $441 | In Stock | In Stock | |
| 100 mg | $596 | In Stock | In Stock | |
| 200 mg | $791 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $125 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.21%
Appearance:Solid
Color:White
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Product Introduction
N-Me-aminopyrimidinone9 AI Summary
N-Me-aminopyrimidinone9 exhibits various bioactivities, suggesting its potential as a sodium channel blocker with effects on both Nav1.7 and Nav1.5 channels. It may interact with hERG channels, as indicated by its ability to displace dofetilide. The compound's efflux ratio suggests it could be a substrate or inhibitor of MDR1. Solubility data in different media provide insights into its formulation and bioavailability. Metabolic potential is indicated by its intrinsic clearance in liver microsomes. Pharmacokinetic parameters including clearance, volume of distribution, and half-life reveal its distribution and elimination characteristics. Toxicity assessments on rat behavior point to potential adverse effects, and its fraction unbound and brain-to-plasma ratio inform about its distribution in the body. Additionally, its relative potency on sodium channels is suggested by its IC50 ratio. The compound's effects are cell-type dependent, showing varying influences on cell viability across HEK293T, U2OS, and human fibroblast cells. Although it has metabolic clearance and distribution characteristics, potential toxicity concerns need to be considered..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-Me-aminopyrimidinone9 is a sodium channel antagonist |
| Molecular Weight | 303.42 |
| Formula | C16H21N3OS |
| Cas No. | 1356834-62-2 |
| Smiles | S(CC1=CC=C(C(C)(C)C)C=C1)C=2N(C)C(=O)C=C(N)N2 |
| Relative Density. | 1.17 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (39.55 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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