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N-Acetyl lysyltyrosylcysteine amide

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Catalog No. T38063Cas No. 1287585-40-3

N-Acetyl lysyltyrosylcysteine amide is a non-toxic, potent, reversible, and specific myeloperoxidase (MPO) tripeptide inhibitor that effectively inhibits MPO production in vivo, attenuates neuronal damage, preserves brain tissue and neurological function post-stroke, and inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration, and LDL oxidation. It is also used in the study of bronchial dysplasia.

N-Acetyl lysyltyrosylcysteine amide
Other Forms of N-Acetyl lysyltyrosylcysteine amide:
N-Acetyl lysyltyrosylcysteine amide acetateT38063L
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N-Acetyl lysyltyrosylcysteine amide

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Purity: 99.02%
Catalog No. T38063Cas No. 1287585-40-3
N-Acetyl lysyltyrosylcysteine amide is a non-toxic, potent, reversible, and specific myeloperoxidase (MPO) tripeptide inhibitor that effectively inhibits MPO production in vivo, attenuates neuronal damage, preserves brain tissue and neurological function post-stroke, and inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration, and LDL oxidation. It is also used in the study of bronchial dysplasia.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$72In StockIn Stock
5 mg$183In StockIn Stock
10 mg$313In StockIn Stock
25 mg$528In StockIn Stock
50 mg$753In StockIn Stock
100 mg$987In Stock-
500 mg$1,980InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.02%
Appearance:Solid
Color:White
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COA HPLC MS

Product Introduction

Bioactivity
Description
N-Acetyl lysyltyrosylcysteine amide is a non-toxic, potent, reversible, and specific myeloperoxidase (MPO) tripeptide inhibitor that effectively inhibits MPO production in vivo, attenuates neuronal damage, preserves brain tissue and neurological function post-stroke, and inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration, and LDL oxidation. It is also used in the study of bronchial dysplasia.
In vivo
N-Acetyl lysyltyrosylcysteine amide (KYC) (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) significantly reduces neurological severity scores and infarct size in MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days) significantly protects BBB function and decreased neutrophil infiltration.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days; C57BL/6J mice) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) decreases apoptosis and cell injury in the brains of MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.[1]
Chemical Properties
Molecular Weight453.56
FormulaC20H31N5O5S
Cas No.1287585-40-3
Smiles[C@@H](CC1=CC=C(O)C=C1)(NC([C@H](CCCCN)NC(C)=O)=O)C(N[C@H](C(N)=O)CS)=O
Relative Density.1.273 g/cm3 (Predicted)
SequenceAc-Lys-Tyr-Cys-NH2
Sequence ShortKYC
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (121.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2048 mL11.0239 mL22.0478 mL110.2390 mL
5 mM0.4410 mL2.2048 mL4.4096 mL22.0478 mL
10 mM0.2205 mL1.1024 mL2.2048 mL11.0239 mL
20 mM0.1102 mL0.5512 mL1.1024 mL5.5119 mL
50 mM0.0441 mL0.2205 mL0.4410 mL2.2048 mL
100 mM0.0220 mL0.1102 mL0.2205 mL1.1024 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-Acetyl lysyltyrosylcysteine AmideNAcetyl lysyltyrosylcysteine amideN Acetyl lysyltyrosylcysteine amideMPOGlutathionePeroxidaseGlutathione Peroxidase
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