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N-Acetyl lysyltyrosylcysteine amide

Catalog No. T38063 CAS 1287585-40-3

N-Acetyl lysyltyrosylcysteine amide is a non-toxic myeloperoxidase (MPO) tripeptide inhibitor that is potent, reversible, and specific.N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO production in vivo. N-Acetyl lysyltyrosylcysteine amide attenuates neuronal damage and preserves brain tissue and neurological function in the post-stroke brain.N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration and LDL oxidation.N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, and specific agent. N-Acetyl lysyltyrosylcysteine amide is used in the study of bronchial dysplasia.

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N-Acetyl lysyltyrosylcysteine amide Chemical Structure

N-Acetyl lysyltyrosylcysteine amide, CAS 1287585-40-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 72.00
5 mg	In stock	$ 183.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 528.00
50 mg	In stock	$ 753.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00

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Purity: 98.08%

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Description

In vivo

N-Acetyl lysyltyrosylcysteine amide (KYC) (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) significantly reduces neurological severity scores and infarct size in MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days) significantly protects BBB function and decreased neutrophil infiltration.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 7 days; C57BL/6J mice) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days; C57BL/6J mice) decreases apoptosis and cell injury in the brains of MCAO mice.[1]
N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.[1]

Molecular Weight	453.56
Formula	C20H31N5O5S
CAS No.	1287585-40-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yu G, et al. Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke [published correction appears in J Neuroinflammation. 2016;13(1):166]. J Neuroinflammation. 2016;13(1):119. Published 2016 May 24. 2. Zhang H, et al. N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. J Lipid Res. 2013;54(11):3016-3029.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Peptide Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

N-Acetyl lysyltyrosylcysteine amide 1287585-40-3 Metabolism Glutathione Peroxidase NAcetyl lysyltyrosylcysteine amide N-Acetyl lysyltyrosylcysteine Amide N Acetyl lysyltyrosylcysteine amide inhibitor inhibit

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