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Nefazodone

Name: Nefazodone
Brand: TargetMol
SKU: T21451
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21451Cas No. 83366-66-9

Alias Serzone, Nefadar, Dutonin

Nefazodone (Nefadar) is an oral antidepressant that is an antagonist of postsynaptic 5-HT 2A receptor and 5-HT 2C receptor, and also inhibits the reuptake of norepinephrine, dopamine, and serotonin (SNDRI).

Nefazodone

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Purity: 99.85%

Catalog No. T21451Alias Serzone, Nefadar, DutoninCas No. 83366-66-9

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$54	In Stock	In Stock
10 mg	$86	In Stock	In Stock
25 mg	$182	In Stock	In Stock
50 mg	$283	In Stock	In Stock
100 mg	$433	In Stock	In Stock
200 mg	$629	-	In Stock
1 mL x 10 mM (in DMSO)	$94	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.85%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Nefazodone (Nefadar) is an oral antidepressant that is an antagonist of postsynaptic 5-HT 2A receptor and 5-HT 2C receptor, and also inhibits the reuptake of norepinephrine, dopamine, and serotonin (SNDRI).
In vitro	Nefazodone inhibited mitochondrial respiration in isolated rat liver mitochondria and in intact HepG2 cells, where this was accompanied by simultaneous acceleration of glycolysis. At the concentration of 200 μM over 24 hours, nefazodone depletes 100% of ATP in both glucose and galactose-grown HepG2 cells. At the concentrations of 6.25, 12.5, and 25 μM within 120 minutes, nefazodone suppresses oxygen consumption in HepG2 cells, indicating strong mitochondrial respiratory inhibition in HepG2 cells. [1]
In vivo	Nefazodone (10 mg/kg/day, s.c) demonstrated immunoprotective effects in mice subjected to chronic auditory stress by partially reversing stress-induced reductions in thymus and spleen cellularity, peripheral T-lymphocyte levels, lymphocyte proliferative response to concanavalin A, and phagocytic activity (assessed via zymosan and carbon clearance tests). Nefazodone had no significant impact on these immune parameters in unstressed mice, indicating a selective protective role under stress conditions. [2]
Synonyms	Serzone, Nefadar, Dutonin

Chemical Properties

Molecular Weight	470.01
Formula	C₂₅H₃₂ClN₅O₂
Cas No.	83366-66-9
Smiles	O=C1N(N=C(N1CCOC=2C=CC=CC2)CC)CCCN3CCN(C=4C=CC=C(Cl)C4)CC3
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 125 mg/mL (265.95 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1276 mL	10.6381 mL	21.2761 mL	106.3807 mL
5 mM	0.4255 mL	2.1276 mL	4.2552 mL	21.2761 mL
10 mM	0.2128 mL	1.0638 mL	2.1276 mL	10.6381 mL
20 mM	0.1064 mL	0.5319 mL	1.0638 mL	5.3190 mL
50 mM	0.0426 mL	0.2128 mL	0.4255 mL	2.1276 mL
100 mM	0.0213 mL	0.1064 mL	0.2128 mL	1.0638 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc