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PKI 14-22 amide, myristoylated Acetate

🥰Excellent
Catalog No. T21983L
Alias PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)

PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. 

PKI 14-22 amide, myristoylated Acetate

PKI 14-22 amide, myristoylated Acetate

🥰Excellent
Purity: 96.34%
Catalog No. T21983LAlias PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. 
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$298In StockIn Stock
5 mg$671In StockIn Stock
10 mg$997In StockIn Stock
25 mg$1,480In StockIn Stock
50 mg$1,990In StockIn Stock
100 mg$2,690In StockIn Stock
1 mL x 10 mM (in DMSO)$1,290In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.34%
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COA HPLC MS

Product Introduction

Bioactivity
Description
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. 
In vitro
?Myristoylated PKI 14-22 amide reduced the IgG-mediated phagocytic response in a manner of dose-dependent.?When the concentration is higher than 10 μM, PKI 14-22 amide can inhibit neutrophil adhesion, which make the phagocytosis measurements impossible to perform
SynonymsPKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)
Chemical Properties
Molecular Weight1269.54
FormulaC55H104N20O14
SmilesCC[C@H](C)[C@@H](C(N)=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC(CNC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.1.31g/cm3
Sequencemyristoyl-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Sequence ShortGRTGRRNAI
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (43.32 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.7877 mL3.9384 mL7.8769 mL39.3843 mL
5 mM0.1575 mL0.7877 mL1.5754 mL7.8769 mL
10 mM0.0788 mL0.3938 mL0.7877 mL3.9384 mL
20 mM0.0394 mL0.1969 mL0.3938 mL1.9692 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PKI 14-22 amide, myristoylated AcetatePKI 1422 amide, myristoylated AcetatePKI 14 22 amide, myristoylated AcetatePKA
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