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Dihexa

Name: Dihexa
Brand: TargetMol
SKU: T7376
Price: 63 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7376Cas No. 1401708-83-5

Alias PNB-0408, N-hexanoic-Try-Ile-(6)-amino hexanoic amide, Hexanoyl-Tyr-Ile-Ahx-NH2

Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.

Dihexa

😃Good

Catalog No. T7376Alias PNB-0408, N-hexanoic-Try-Ile-(6)-amino hexanoic amide, Hexanoyl-Tyr-Ile-Ahx-NH2Cas No. 1401708-83-5

Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$63	In Stock	In Stock
2 mg	$87	In Stock	In Stock
5 mg	$135	In Stock	In Stock
10 mg	$229	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$569	In Stock	In Stock
100 mg	$787	-	In Stock
200 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:≥95%

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.
Targets&IC50	HGF:65 pM(kd)
In vivo	Dihexa (2 mg/kg, i.p.) completely reverses scopolamine-induced learning deficits in the latency to find the platform and increases the time spent in the target quadrant in the Morris water maze in rats[1]
Synonyms	PNB-0408, N-hexanoic-Try-Ile-(6)-amino hexanoic amide, Hexanoyl-Tyr-Ile-Ahx-NH2

Chemical Properties

Molecular Weight	504.66
Formula	C₂₇H₄₄N₄O₅
Cas No.	1401708-83-5
Smiles	[C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(NCCCCCC(N)=O)=O)[C@H](CC)C)=O)NC(CCCCC)=O
Relative Density.	1.111 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (495.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9815 mL	9.9077 mL	19.8153 mL	99.0766 mL
5 mM	0.3963 mL	1.9815 mL	3.9631 mL	19.8153 mL
10 mM	0.1982 mL	0.9908 mL	1.9815 mL	9.9077 mL
20 mM	0.0991 mL	0.4954 mL	0.9908 mL	4.9538 mL
50 mM	0.0396 mL	0.1982 mL	0.3963 mL	1.9815 mL
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc