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Thalidomide-O-amido-C4-N3

🥰Excellent
Catalog No. T15189Cas No. 2098488-36-7
Alias E3 ligase Ligand-Linker Conjugates 18, Cereblon Ligand-Linker Conjugates 4

Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.

Thalidomide-O-amido-C4-N3

Thalidomide-O-amido-C4-N3

🥰Excellent
Purity: 97.01%
Catalog No. T15189Alias E3 ligase Ligand-Linker Conjugates 18, Cereblon Ligand-Linker Conjugates 4Cas No. 2098488-36-7
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
Pack SizePriceAvailabilityQuantity
2 mg$51In Stock
5 mg$83In Stock
10 mg$122In Stock
25 mg$197In Stock
50 mg$298In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Batch Information

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Purity:97.01%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
SynonymsE3 ligase Ligand-Linker Conjugates 18, Cereblon Ligand-Linker Conjugates 4
Chemical Properties
Molecular Weight428.4
FormulaC19H20N6O6
Cas No.2098488-36-7
SmilesO=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCN=[N+]=[N-])=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (93.37 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3343 mL11.6713 mL23.3427 mL116.7134 mL
5 mM0.4669 mL2.3343 mL4.6685 mL23.3427 mL
10 mM0.2334 mL1.1671 mL2.3343 mL11.6713 mL
20 mM0.1167 mL0.5836 mL1.1671 mL5.8357 mL
50 mM0.0467 mL0.2334 mL0.4669 mL2.3343 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Thalidomide-O-amido-C4-N3Thalidomide-O-amido-C-4-N3ThalidomideOamidoC4N3Thalidomide O amido C4 N3LigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 Ligase Ligand-Linker ConjugatesCereblon
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