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Zolantidine dimaleate

Name: Zolantidine dimaleate
Brand: TargetMol
SKU: T23565
Rating: 4.5 (1 reviews)

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Catalog No. T23565Cas No. 104076-39-3

Zolantidine dimaleate represents the first-in-class, brain-penetrating histamine H2 receptor antagonist cross the blood-brain barrier with high efficiency to modulate histaminergic signaling within the central nervous system during various preclinical experimental protocols.

Zolantidine dimaleate

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Catalog No. T23565Cas No. 104076-39-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	6-8 weeks	6-8 weeks
5 mg	$262	6-8 weeks	6-8 weeks
10 mg	$389	35 days	35 days
25 mg	$638	6-8 weeks	6-8 weeks
50 mg	$882	35 days	35 days
100 mg	$1,190	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Zolantidine dimaleate represents the first-in-class, brain-penetrating histamine H2 receptor antagonist cross the blood-brain barrier with high efficiency to modulate histaminergic signaling within the central nervous system during various preclinical experimental protocols.
Targets&IC50	H2 Receptor:~40 nM
In vitro	In physiological recordings using guinea-pig atrium, Zolantidine dimaleate antagonized histamine H2-receptors with a pA2 value of 6.57 [1].
In vivo	In rat models, intravenous administration of Zolantidine dimaleate (1-10 umol/kg) inhibited gastric acid secretion and attenuated behavioral changes [1].

Chemical Properties

Molecular Weight	497.61
Formula	C₂₆H₃₁N₃O₅S
Cas No.	104076-39-3
Smiles	C(=C\C(O)=O)\C(O)=O.N(CCCOC1=CC(CN2CCCCC2)=CC=C1)C3=NC=4C(S3)=CC=CC4
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (80.38 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0096 mL	10.0480 mL	20.0961 mL	100.4803 mL
5 mM	0.4019 mL	2.0096 mL	4.0192 mL	20.0961 mL
10 mM	0.2010 mL	1.0048 mL	2.0096 mL	10.0480 mL
20 mM	0.1005 mL	0.5024 mL	1.0048 mL	5.0240 mL
50 mM	0.0402 mL	0.2010 mL	0.4019 mL	2.0096 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc