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Methscopolamine

Name: Methscopolamine
Brand: TargetMol
SKU: T0253
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0253Cas No. 155-41-9

Alias Methscopolamine bromide, Hyoscine methyl bromide, (-)-Scopolamine methyl bromide

Methscopolamine (Hyoscine methyl bromide) (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.

Methscopolamine

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Purity: 99.13%

Catalog No. T0253Alias Methscopolamine bromide, Hyoscine methyl bromide, (-)-Scopolamine methyl bromideCas No. 155-41-9

Methscopolamine (Hyoscine methyl bromide) (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$42	In Stock	In Stock
50 mg	$50	In Stock	In Stock
100 mg	$71	In Stock	In Stock
200 mg	$118	In Stock	In Stock
500 mg	$195	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.13%

Color:White

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COA LCMS HNMR

Product Introduction

Methscopolamine AI Summary

Methscopolamine exhibits various bioactivities and potential therapeutic implications. With a potency of 8912.5 nM, it inhibits and activates N370S glucocerebrosidase, highlighting its potential as a chaperone treatment for Gaucher Disease. For inducing DNA re-replication in MCF 10a normal breast cells, it shows a potency of 517.4 nM. In assays focusing on blocking the entry of Ebola virus, Methscopolamine demonstrates varied AC50 values: 10000.0 nM and 10.0 uM in green channel assays, and 0.631 uM and 631.0 nM in blue channel assays. Liver toxicity studies indicate a severity class index of 0.0, suggesting no drug-induced liver injury in humans. The compound also shows antiviral activity against SARS-CoV-2, with 7.48% inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells at 10 uM after 48 hours, and 40.49% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM. It exhibits -0.03% inhibition of cytotoxicity in VERO-6 cells at the same concentration and exposure time. Additionally, Methscopolamine shows inhibitory activity on human HDAC6, with -9.26% inhibition using a commercial peptide substrate and 2.15% inhibition with a custom peptide substrate in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methscopolamine (Hyoscine methyl bromide) (Pamine), as a natural plant alkaloid, is a muscarinic acetylcholine receptor blocker.
Synonyms	Methscopolamine bromide, Hyoscine methyl bromide, (-)-Scopolamine methyl bromide

Chemical Properties

Molecular Weight	398.29
Formula	C₁₈H₂₄BrNO₄
Cas No.	155-41-9
Smiles	[Br-].[H][C@]12O[C@@]1([H])[C@]1([H])C[C@@H](C[C@@]2([H])[N+]1(C)C)OC(=O)[C@H](CO)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 61 mg/mL (153.15 mM), Sonication is recommended.

DMSO: 50 mg/mL (125.54 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5107 mL	12.5537 mL	25.1073 mL	125.5367 mL
5 mM	0.5021 mL	2.5107 mL	5.0215 mL	25.1073 mL
10 mM	0.2511 mL	1.2554 mL	2.5107 mL	12.5537 mL
20 mM	0.1255 mL	0.6277 mL	1.2554 mL	6.2768 mL
50 mM	0.0502 mL	0.2511 mL	0.5021 mL	2.5107 mL
100 mM	0.0251 mL	0.1255 mL	0.2511 mL	1.2554 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc