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Devapamil

Name: Devapamil
Brand: TargetMol
SKU: T68055
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68055Cas No. 92302-55-1

Alias Devapamilum, Devapamilo

Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.

Devapamil

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Purity: 99.63%

Catalog No. T68055Alias Devapamilum, DevapamiloCas No. 92302-55-1

Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	-	In Stock
5 mg	$180	-	In Stock
10 mg	$260	-	In Stock
25 mg	$506	-	In Stock
50 mg	$680	-	In Stock
100 mg	$968	-	In Stock
500 mg	$1,930	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Oil

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.
In vitro	Devapamil (3 μM) reduced L-type calcium currents (ICa) to 16.1 +/- 8.6%, 11 +/- 8.9%, and 9.3 +/- 6% of control, respectively. Intracellular application of the same substances, via the patch pipette filled with 30 μM of devapamil, failed to depress ICa. The quaternary derivatives of the phenylalkylamines (30 microM) were ineffective both when applied extracellularly or intracellularly. It is suggested that phenylalkylamines block ICa in ventricular myocytes by acting on a binding site of the calcium channel molecule located at the outer surface of the cell membrane.[3]
Synonyms	Devapamilum, Devapamilo

Chemical Properties

Molecular Weight	424.58
Formula	C₂₆H₃₆N₂O₃
Cas No.	92302-55-1
Smiles	C(CCCN(CCC1=CC(OC)=CC=C1)C)(C(C)C)(C#N)C2=CC(OC)=C(OC)C=C2

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (117.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3553 mL	11.7763 mL	23.5527 mL	117.7634 mL
5 mM	0.4711 mL	2.3553 mL	4.7105 mL	23.5527 mL
10 mM	0.2355 mL	1.1776 mL	2.3553 mL	11.7763 mL
20 mM	0.1178 mL	0.5888 mL	1.1776 mL	5.8882 mL
50 mM	0.0471 mL	0.2355 mL	0.4711 mL	2.3553 mL
100 mM	0.0236 mL	0.1178 mL	0.2355 mL	1.1776 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc