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Devapamil

Catalog No. T68055 CAS 92302-55-1

Synonyms: Devapamilo, Devapamilum

Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.

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Devapamil, CAS 92302-55-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 180.00
10 mg	In stock	$ 260.00
25 mg	In stock	$ 506.00
50 mg	In stock	$ 680.00
100 mg	In stock	$ 968.00
500 mg	In stock	$ 1,930.00

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Purity: 100%

Biological Description

Chemical Properties

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Description

Devapamil (Devapamilo) is a phenylalkylamine that blocks L-type calcium currents from the inner side of membrane cells in a use-dependent manner.

In vitro

Devapamil (3 μM) reduced L-type calcium currents (ICa) to 16.1 +/- 8.6%, 11 +/- 8.9%, and 9.3 +/- 6% of control, respectively. Intracellular application of the same substances, via the patch pipette filled with 30 μM of devapamil, failed to depress ICa. The quaternary derivatives of the phenylalkylamines (30 microM) were ineffective both when applied extracellularly or intracellularly. It is suggested that phenylalkylamines block ICa in ventricular myocytes by acting on a binding site of the calcium channel molecule located at the outer surface of the cell membrane.[3]

Synonyms	Devapamilo, Devapamilum
Molecular Weight	424.58
Formula	C26H36N2O3
CAS No.	92302-55-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (117.76 mM)

References and Literature

1. Erdmann R, et al. The effect of the phenylalkylamine D888 (devapamil) on force and Ca2+ current in isolated frog skeletal muscle fibres. J Physiol. 1989;413:521-541. 2. Schneider T, et al. The devapamil-binding site of the purified skeletal muscle receptor for organic-calcium channel blockers is modulated by micromolar and millimolar concentrations of Ca2+. Eur J Biochem. 1991;200(1):245-253. 3. Wegener JW, et al. Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1995;352(3):322-330.

Related compound libraries

This product is contained In the following compound libraries：

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Devapamil 92302-55-1 Membrane transporter/Ion channel Metabolism Calcium Channel Devapamilo Devapamilum inhibitor inhibit

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