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ZJ 43
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Catalog No. T21837Cas No. 723331-20-2
ZJ43 is a potent inhibitor of glutamate carboxypeptidase II (K(i) = 0.8 nM) and III (K(i) = 23 nM) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models [1].
ZJ 43
😃Good
Catalog No. T21837Cas No. 723331-20-2
ZJ43 is a potent inhibitor of glutamate carboxypeptidase II (K(i) = 0.8 nM) and III (K(i) = 23 nM) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,365 | 6-8 weeks | |
| 50 mg | $2,785 | 6-8 weeks | |
| 100 mg | $3,520 | 6-8 weeks |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZJ43 is a potent inhibitor of glutamate carboxypeptidase II (K(i) = 0.8 nM) and III (K(i) = 23 nM) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models [1]. |
| Molecular Weight | 607.59 |
| Formula | C24H39N4O14 |
| Cas No. | 723331-20-2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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