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Nexopamil

Name: Nexopamil
Brand: TargetMol
SKU: T28164
Price: 72 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28164Cas No. 136033-49-3

Alias LU-49938, LU49938, LU 49938

Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.

Nexopamil

🥰Excellent

Purity: 99.84%

Catalog No. T28164Alias LU-49938, LU49938, LU 49938Cas No. 136033-49-3

Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$72	In Stock	In Stock
5 mg	$173	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$437	In Stock	In Stock
50 mg	$646	In Stock	In Stock
100 mg	$919	In Stock	In Stock
200 mg	$1,250	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.84%

ee:100%

Color:White

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COA HPLC CSFC HNMR

Product Introduction

Bioactivity

Description	Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.
In vitro	Nexopamil abolished in a concentration-dependent way the serotonin-induced [3H]thymidine incorporation into DNA, and the serotonin-induced increase in a number of cells. Nexopamil partially blocked the serotonin-induced mesangial cell contraction, in a dose-dependent manner blocking 5-HT2 receptors and the voltage-operated Ca2+ channels.[3]
Synonyms	LU-49938, LU49938, LU 49938

Chemical Properties

Molecular Weight	404.59
Formula	C₂₄H₄₀N₂O₃
Cas No.	136033-49-3
Smiles	[C@@](CCCN(CCCCCC)C)(C(C)C)(C#N)C1=CC(OC)=C(OC)C(OC)=C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (135.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4716 mL	12.3582 mL	24.7164 mL	123.5819 mL
5 mM	0.4943 mL	2.4716 mL	4.9433 mL	24.7164 mL
10 mM	0.2472 mL	1.2358 mL	2.4716 mL	12.3582 mL
20 mM	0.1236 mL	0.6179 mL	1.2358 mL	6.1791 mL
50 mM	0.0494 mL	0.2472 mL	0.4943 mL	2.4716 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2358 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc