p 1

P1 is a broad-spectrum antimicrobial peptide effective against both Gram-positive and Gram-negative bacteria, including B. anthracis spores and Carbapenem-resistant strains of A. baumannii and K. pneumoniae [1].

GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a).

Micrococcin P1 is a macrocyclic peptide antibiotic and a potent inhibitor of the hepatitis C virus (HCV) with an EC50 range of 0.1-0.5 μM.

PDI-IN-P1 is an inhibitor of protein disulfide isomerase.

SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. It suppresses the survival of Y cells and Y stem cells by triggering cell senescence and inhibiting glycolysis. It exhibits antitumor effects in multiple animal models and Y cell lines.

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

Cecropin P1, porcine, is an antibacterial peptide first identified in moths (Hyalophora cecropia) and subsequently found in pig intestines.

Cecropin P1 (porcine acetate) is an antibacterial peptide present in Hyalophora cecropia and the pig intestine.

THZ-P1-2 is a selective and potent PI5P4K inhibitor with anti-leukemic activity that acts by disrupting mitochondrial homeostasis and autophagy.THZ-P1-2 induces cell death and mitochondrial damage, and can be used in the study of leukemias.

PtdIns-(3)-P1 (1,2-dipalmitoyl) (Compound 7) ammonium is a derivative of phosphatidylinositol 3-phosphate. This compound interacts with the FYVE domain of human EEA1, functioning as a second messenger in cellular signal transduction and membrane transport. Additionally, phosphatidylinositol 3-phosphate can stimulate ROS formation by regulating the neutrophil oxidase complex.

PtdIns-(4)-P1-(1,2-dihexanoyl) sodium is a synthetic phosphatidylinositol (PtdIns) derivative. It serves as a model membrane phospholipid for in vitro enzymatic studies.

PtdIns-(5)-P1-(1,2-dioctanoyl) ammonium is a synthetic derivative of phosphatidylinositol (PtdIns). It serves as a model membrane phospholipid for use in in vitro enzymatic research.

TTA-P1 is a highly potent compound that effectively inhibits human T-type calcium channels, which are involved in various physiological processes such as neuronal burst firing, hormone secretion, and cell growth. With its unique state-independent properties, TTA-P1 holds promising potential for advancing research on absence epilepsy [1].

Nuclease P1, renowned for its specificity to single-stranded regions within double-stranded nucleic acids, acts as an endonuclease by hydrolyzing nucleic acids into 5'-mononucleotides. Its distinct ability to cleave single-stranded portions makes it a pivotal tool in molecular biology, with widespread applications in both the pharmaceutical and food industries [1].

PTBP1α3-helix derived peptide P1 is a polypeptide that inhibits RNA binding [1].

P1,P2-Diuridine-5'-diphosphate (Up2U) is a symmetrical dinucleoside polyphosphate featuring two pyrimidine base components. It also acts as an agonist for the purinergic P2Y receptor (purinergic P2Y receptor).

Ketorolac-D5-P1 is a deuterated compound of Ketorolac. Ketorolac (T21412) has a CAS number of 74103-06-3. Ketorolac (T21412) is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.

Thiothixene-D8 P1 is a deuterated compound of Thiothixene. Thiothixene (T38200) has a CAS number of 3313-26-6. (Z)-Thiothixene is an antagonist of serotonergic receptor.

Polymyxin P1 can be produced by Paenibacillus polymyxa T-39 and has the ability to inhibit Gram-positive bacteria.

Ptd-p65-p1 Peptide TFA is a nuclear transcription factor nf-kappab inhibitor, consisting of a membrane transport Peptide sequence derived from antennapedia linked to p65-p1, selectively inhibiting nf-kappab activity induced by various stimuli.

PTD-p65-P1 Peptide, a selective inhibitor of the nuclear transcription factor NF-kappaB, consists of a conjugation between a membrane-translocating peptide derived from antennapedia (PTD) and p65-P1. This composition effectively inhibits activation triggered by diverse inflammatory stimuli.

BTM-P1 is a polycationic peptide that exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. It disrupts mitochondrial energy processes by forming ion-permeable channels in the mitochondrial inner membrane.

DBCO-tag peptide P1 is a cysteine-containing peptide tag that selectively reacts with dibenzocyclooctyne (DBCO) to form a stable dibenzocyclooctenyl thioether. This peptide allows for site-specific labeling of mEGFP and antibodies (such as Trastuzumab) without affecting protein binding function. DBCO-tag peptide P1 is useful for ADC synthesis and mEGFP labeling research.

Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.