PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can

PACAP-38 (31-38), human, mouse, rat acetate (0.01-10 nM; HEK 293 cells) stimulates neural cells to express endogenous PAC1 receptors by cAMP accumulation and by an increase in cytosolic free calcium and induces elevation of the intracellular Ca2+ concentration in a dose-dependent manner with an EC50 value of 0.81 nM. PACAP-38 (31-38), human, mouse, rat acetate (300 nM; 4 h) stimulates the generation of APPsα in neural cells[1]. PACAP-38 (31-38), human, mouse, rat acetate (0.01 nM; 48 h) elicits potent and efficacious stimulation of NPY secretion from SCG neuronal cultures[2]. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 14 d) produces sustained stimulated NPY and catecholamine secretionmpathetic neurons[2]. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 2 min; NCI-H838 cells) induces EGFR, HER2, and ERK tyrosine phosphorylation. PACAP-38 (31-38), human, mouse, rat acetate (10 nM; 48 h) stimulates the growth of NCI-H838 cells. PACAP-38 (31-38), human, mouse, rat acetate (100 nM; 30 min; NCI-H838 cells) induces EGFR tyrosine phosphorylation with generates ROS and increases ROS levels by 51%[3].