c-c

C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl ether-based PROTAC linker used for synthesizing PROTACs [1].

C-NH-Boc-C-Bis-(C1-PEG1-PFP), a polyethylene glycol (PEG)-derived PROTAC linker, is utilized in the synthesis of PROTACs [1].

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker used in the development of antibody-drug conjugates (ADCs).

(S,R,S)-AHPC-CO-C-cyclohexane serves as an E3 Ligase Ligand-Linker Conjugate. This chemical compound is utilized in the synthesis of PROTAC SMARCA2 4-degrader-14.

Lenalidomide-6-F-piperidine-C2-Pip-C-COOH acts as a linker and an E3 ligase ligand for PROTACBTKDegrader-5, utilized in the study of malignant lymphomas.

Piperidine-C2-Pip-C-COOH serves as a linker for PROTAC BTK Degrader-5, significantly enhancing metabolic stability for use in cancer research.

trans-VH032-Cyclopropane-F-C-cyclohexane-p-C-OTs contains a VHL ligand for recruiting E3 ubiquitin ligase and a PROTAC linker. VHL Ligand-Linker Conjugates 15 is applicable for the synthesis of PROTACs, such as dBAZ2B.

trans-VH 101-Thiol-C-cyclohexane-p-C-OTs is a conjugate of the E3 ligase VHL ligand and linker, employed for the synthesis of the PROTAC degrader dBAZ2.

N-Ac-Cys-C-lock-G5-DUO-5 is a part of ADC. DUO-5 is a microtubule inhibitor and a new type of toxin molecule with anti-cancer activity.

CB1 receptor inverse agonist

c-Ceritinib TFA salt is a coupleable ceritinib analog with a linker which also binds multiple other kinases, including FAK1, RSK1/2, ERK1/2, CAMKK2 and FER.

OH-C-Chol is a cationic cholesterol derivative. As a component of lipoplexes with DOPE, OH-C-Chol has been utilized for siRNA delivery and gene silencing in MCF-7 cells and in mice through intravenous injection, leading to lipoplex accumulation in the liver.

CHO-C-PEG2-C-CHO is a PEG-based linker for PROTACs that connects two essential ligands necessary for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is utilized in lymphoma research [1].

2'-OMe-Ac-C Phosphoramidite, a modified phosphoramidite, is utilized in the synthesis of oligonucleotides.

Cys-C-cGMP serves as an autophagy tag for AUTACs (autophagy-targeting chimeras). It enhances K63-linked ubiquitination of mitochondria within HeLa cells [1].

Compound IM-3, known as Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH, functions as a cleavable ADC linker [1].

(S,R,S)-AHPC-CO-C-piperazine is a conjugate of an E3 ubiquitin ligase ligand-linker.

SMARCA2 4-ligand-Linker Conjugate-4 is an E3 ubiquitin ligase ligand-linker conjugate.

SMARCA2 4-ligand-Linker Conjugate-8 is an E3 ubiquitin ligase ligand-linker conjugate.

C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.

C-021 dihydrochloride is a potent CCR4 antagonist that effectively inhibits functional chemotaxis in humans and mice, with IC50 values of 140 nM and 39 nM, respectively.

c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).